May 2, 2022 · Mucinous carcinoma is a rare type of cancer. It starts in the main component of mucus, the mucin. This cancer can occur anywhere, but is most common in your breast.

Sep 18, 2018 · Mucinous carcinoma consists of cancer cells and mucin, the substance that makes up mucus. What part of the body does this cancer affect and what is its survival rate?

Metastatic urothelial cancer (mUC) is a molecularly heterogeneous disease with diverse potential drivers of progression and mechanisms of therapeutic response and resistance. 1 For over 3 decades, platinum-based chemotherapy has been the standard of care (SOC) treatment for these patients, but this paramount will rapidly change after the recent ...

Mucin 1 (MUC1) was the first discovered transmembrane protein of the mucin family; it normally covers epithelial cells of the mucous membrane, providing lubrication and protection. However, aberrant expression of MUC1 is involved in cancer ...

A clinical trial for metastatic urothelial carcinoma (mUC) explores the potential for new treatment options against one of the deadliest bladder cancers.

The human mucin (MUC) family consists of members — designated MUC1 to MUC21 — that have been sub-classified into secreted and transmembrane forms.

However, in cancer cells, MUC1 often undergoes aberrant glycosylation and overexpression. It is involved in cancer invasion, metastasis, angiogenesis, and apoptosis by virtue of its participation in intracellular signaling processes and the regulation of related biomolecules.

Jul 7, 2022 · Vinit Makkar, MD, provides a brief overview of locally advanced/metastatic urothelial carcinoma (la/mUC), available first-line (1L) and first-line maintenance (1LM) treatment options, and unmet needs in the field.

This review highlights the structural and functional differences that exist between normal and tumor-associated MUC1. We also discuss the recent advances made in the use of MUC1 as a biomarker and therapeutic target for cancer.

The following article reviews the available systemic therapies studied in the patient collective with mUC after prior CPI therapy. In the article, mUC is used as an umbrella term for mUC or locally advanced and unresectable UC (i.e., Stage III or IV disease).