The mTOR pathway is a central regulator of mammalian metabolism and physiology, with important roles in the function of tissues including liver, muscle, white and brown adipose …

In this review, we provide an overview of our current understanding of the mTOR pathway and its role in growth, metabolism, and disease.

mTORC1, also known as mammalian target of rapamycin complex 1 or mechanistic target of rapamycin complex 1, is a protein complex that functions as a nutrient/energy/redox sensor …

4 days ago · Discover the mTOR pathway and its role in cellular growth and metabolism. Click here to explore the intricacies of this vital signaling pathway.

Mar 9, 2020 · There are 4 main functions of the mTOR signaling pathway: cell growth and proliferation, angiogenesis, bioenergetics through nutrient availability and boosting of …

Jan 14, 2020 · The mTOR pathway integrates diverse environmental cues to control biomass accumulation and metabolism by modulating key cellular processes, including protein …

Here, we discuss the mechanistic (or mammalian) target of rapamycin (mTOR) complex 1 (mTORC1) as a nutrient sensing protein kinase that acts as a master regulator of cellular …

Jan 2, 2019 · Mechanistic target of rapamycin (mTOR) controls cell growth mainly by promoting anabolic processes, including protein, lipid and nucleotide synthesis, and by suppressing …

Oct 2, 2023 · The emerging pieces of evidence have revealed that the constitutive activation of the mTOR pathway due to mutations/amplification/deletion in either mTOR and its complexes …

Two major growth signaling pathways, phosphatidylinositol 3-kinase (PI3K)-Akt and Ras-ERK, regulate mTORC1 activity through functional inhibition of the tumor suppressor tuberous …