Jun 21, 2022 · The present application describes a series of novel compounds as MrgX2 (Mas-related Gene X2) antagonists for the treatment of skin disorders, IBD, arthritis, asthma, and …

Recent work has emphasized the role of the Mas-related G protein-coupled receptor (MRGPR) family, specically, Mrgprb2, in mast cell activation. Mrgprb2 is fi the mouse receptor for several …

We showed GSK3212448 to be a potent MrgX2 agonist particularly at rat MrgX2. We screened sets of drug‐like molecules and peptides to confirm the highly promiscuous nature of MrgX2. …

Mas-related G-protein coupled receptor member X2 is a protein that in humans is encoded by the MRGPRX2 gene. [5][6] It is most abundant on cutaneous mast cells, sensory neurons, and …

In this review, we discuss the roles in innate immunity through functional studies on MRGPRX2-mediated IgE-independent MC activation and also the therapeutic potential of MRGPRX2 …

Dec 30, 2011 · This study identified MrgX2 as a novel G protein-coupled receptor for the antibacterial peptide LL-37 and demonstrated that unlike most G protein-coupled receptors it is …

Sep 1, 2022 · Mas-related G-protein coupled receptor X2 (MRGPRX2) is expressed particularly on mast cells and its activation leads to the mast cell degranulation with release of …

Activation of MrgX2, an orphan G protein-coupled receptor expressed on mast cells, leads to degranulation and histamine release.

Dec 2, 2019 · Human MrgX2 binds promiscuously to structurally diverse peptides and small molecules that tend to have basic properties (basic secretagogues), resulting in acute …

Apr 14, 2022 · The present application describes a series of novel compounds as MrgX2 (Mas-related Gene X2) antagonists for the treatment of skin disorders, IBD, arthritis, asthma, and …