The elevated plus maze (EPM) is a test measuring anxiety in laboratory animals that usually uses rodents as a screening test for putative anxiolytic or anxiogenic compounds and as a general …

Jan 26, 2017 · The elevated plus maze (EPM) and elevated zero maze (EZM) are behavioral tests that are widely employed to assess anxiety-like behaviors in rats and mice following …

The elevated plus maze is a widely used behavioral assay for rodents and it has been validated to assess the anti-anxiety effects of pharmacological agents and steroid hormones, and to define …

Nov 7, 2022 · Our data uncover a role of hippocampal astrocytes in modulating mice anxiety-like behaviors by regulating ATP-mediated synaptic homeostasis in hippocampal DG granule cells. …

Dec 20, 2024 · Here, we present a protocol to implement the classical EPM apparatus in a real-time optogenetic environment to address behavioral avoidance in mice. We describe steps for …

Here, we present a detailed movie demonstrating our protocol for the elevated plus maze test. In our laboratory, we have assessed more than 90 strains of mutant mice using the protocol …

Aug 21, 2002 · The elevated plus-maze test (PM) and open-field test (OF) are routinely used to study anxiety-related behaviour in mouse. However, the data obtained with these tests have …

Oct 23, 2023 · Relative to B6 mice, BALB and 129S6 mice, two isogenic mouse strains widely used to model heightened anxiety-like behavior, exhibited less time spent in the open arms as …

The elevated-plus maze (EPM) is a well-established task for assessing anxiety-like conflict behavior in rodents by allowing subjects to choose between entering the open arms of the …

Apr 2, 2018 · Herein, we monitored cortical local field potentials (LFPs), electrocardiograms (ECGs), electromyograms (EMGs), and respiratory signals in individual mice that were …