Jan 1, 2004 · CD20 plays a role in human B cell proliferation and is an effective target for immunotherapy. In this study, mouse CD20 expression and biochemistry were assessed for the first time using a new panel of CD20‐specific mAb, with CD20 function assessed using CD20‐deficient (CD20 –/–) mice.

Altogether, functional studies suggest that CD20 is physiologically directly required for efficient BCR signaling in B cells. This is also in line with some data from the CD20 mouse models.

CD20 plays a role in human B cell proliferation and is an effective target for immunotherapy. In this study, mouse CD20 expression and biochemistry were assessed for the first time using a new panel of CD20-specific mAb, with CD20 function assessed using CD20-deficient (CD20 ( …

Several novel anti-CD20 monoclonal antibodies are currently in development with the aim of improving the treatment of B cell malignancies. Mutagenesis and epitope mapping studies have revealed differences between the CD20 epitopes recognized by these antibodies.

Sep 23, 2019 · The presence of CD20 in each fraction was immunodetected with a mouse anti-CD20 (Abcam, 1:200) as a primary antibody and an anti-mouse IgG HRP conjugate as a secondary antibody (3:10000).

CD20 is an important therapeutic target in the treatment of B cell lymphomas and leukemias. 0.2 µm filtered in phosphate-buffered solution, pH 7.2, containing no preservative. Less than 0.01 EU/µg of the protein (< 0.001 ng/µg of the protein) as determined by the LAL test.

Feb 27, 2019 · We recently assessed the ability of the BLT mice to recapitulate the clinical pharmacokinetics (PKs) and pharmacodynamics (PDs) of rituximab, an anti‐CD20 monoclonal antibody and innovator biological drug product in humans.

Mice were treated with one single dose of 50 or 100 μg mouse anti-mouse CD20 (clone 5D2, isotype IgG2a, Genentech) to evaluate depletion of endogenous or malignant B cells, respectively.

In this study, we investigated the molecular interaction between endogenous CD20 on B cells with three different therapeutic mAbs by TDI-DNA-PAINT, enabling fast whole-cell imaging with virtually molecular resolution by LLS microscopy.

CD20 plays a role in human B cell proliferation and is an effective target for immunotherapy. In this study, mouse CD20 expression and biochemistry were assessed for the first time using a new panel of CD20-specific mAb, with CD20 function assessed using CD20-deficient (CD20(-/-)) mice.