Nov 12, 2022 · Here we report that cortex-wide calcium imaging in mice revealed distinct sleep stage-dependent spatiotemporal patterns of global cortical activity, and modulation of such patterns could regulate...

We focus on estimating features of REM (i.e., time spent in REM, number of bouts, and median bout length) as well as time spent in NREM and WAKE. We also consider the model's epoch-by-epoch scoring performance relative to several alternative approaches.

Mar 24, 2025 · Explore how sleep shapes memory in mice, from brain-wave patterns to neural activity, and the factors that influence rest quality and duration.

For example, in mice, periods of REM sleep occur roughly every 10–15 minutes [38], whereas, in humans, REM sleep periods occur every 90–120 minutes [39, 40]. Why REM sleep amounts and expression differ between animals remains unclear.

Mar 1, 2024 · In this study, we investigated the impact of reactivating these stimulated neurons within the BLA on the sleep/wakefulness states of mice. Additionally, we explored the influence of serotonergic modulation on the role of DA function in the BLA.

Aug 25, 2021 · Our data-driven modeling approach uncovered basic principles underlying the timing and duration of REM sleep episodes in mice and provides a flexible framework to describe the ultradian regulation of REM sleep in health and disease.

Sleep-stage specific distributions of REM in mice correspond to human REM density during sleep. REM density, now also assessable in animal models through our approach, is increased in humans after acute stress, during PTSD and in depression.

Oct 31, 2019 · Sleep in mice consists of three stages: WAKE, non-REM (non-rapid eye movement sleep), and REM (rapid eye movement sleep). These stages play different roles in the lives of mice, and can be...

Oct 22, 2015 · To functionally isolate from the complex mixture of neurons populating the brainstem pons those involved in switching between REM and NREM sleep, we chemogenetically manipulated neurons of a specific embryonic cell lineage in mice.

Mar 3, 2022 · Chemogenetic inhibition of Drd2 neurons in the BLA of Drd2-Cre mice increased REM sleep time and decreased NREM sleep time (Fig. 4, Q to S, and table S4), further supporting the importance of Drd2 neurons in the BLA in triggering REM sleep.