Jun 22, 2022 · Experiments in mice show that the mechanically activated ion channel PIEZO1 is expressed in itch-specific sensory neurons and has a role in transducing mechanical itch.

Our results molecularly characterize the first three stations of an itch response pathway in mice , demonstrate that Nppb marks the primary sensory neurons and show that this peptide is both …

In this paper, we explore how these models have enhanced our understanding of the mechanisms underlying itch through both acute and chronic itch models. We provide detailed protocols and …

Here, we review to what extent mice behaviorally differentiate chemicals that elicit itch vs. pain in humans. The ideal animal model of stimulus evoked itch or pain in humans is one wherein the …

This evidence reveals that the loss of Itch results in multiple phenotypic outcomes that are driven by different mechanisms of immune activation. Itchy mice develop lung and skin inflammation …

Oct 31, 2023 · Chen et al. present a database for itch-evoked responses by conducting fiber photometry across 126 mouse brain areas. Their results reveal a rich diversity of neural …

Sep 25, 2024 · In this paper, we explore how these models have enhanced our understanding of the mechanisms underlying itch through both acute and chronic itch models. We provide …

mouse studies in itch provide a unique opportunity to map itch phenotypes and mechanistically link them to the mo-lecular pathways underlying them. In this paper, we highlight different …

Jan 30, 2025 · Scratching where it itches reduces the presence of potentially harmful bacteria on the skin, studies in mice show.

Loss of PIEZO1 function in peripheral neurons greatly reduces mechanically evoked scratching behaviours and both acute and chronic itch-evoked sensitization. Finally, mice expressing a …