PMA significantly up-regulated the expression of Arg-1 and the Arg-1 protein expression in MDSCs and arginase 1 (Arg-1) inhibitor nor-NOHA reversed the MDSC immunosuppressive …

M‐MDSCs induced by M‐CSF combined with PMA could inhibit T cell proliferation through Arg‐1, and PMA treatment significantly enhanced the MDSC immunosuppressive activity, it showed …

PMA significantly upregulated Arg-1 expression in MDSCs, and an Arg-1 inhibitor (nor-NOHA) diminished MDSC activity . This study confirms that in vitro induced-MDSCs may be promising …

May 3, 2022 · In this review, we discuss the involvement of PMN-MDSC in cancer initiation and progression and their potential as therapeutic targets and clinical biomarkers in different cancers.

In this study we observed a substantial up-regulation of ROS by MDSC in all of seven different tumor models and in patients with head and neck cancer. The increased ROS production by …

Jul 20, 2020 · Here, we report that the spleen in gastric and pancreatic cancer adopts an immune regulatory character, harbors excessive amount of PMN-MDSC, and anatomically enables …

Aug 28, 2021 · The combination of PMA and M-CSF induced the differentiation of myeloid-derived monocytes into MDSCs. MDSCs were found to induce immune tolerance by inhibiting the …

May 2, 2021 · In vivo, PMN-MDSCs existed in higher numbers, correlated with different Th-subsets, and more strongly associated with poor clinical course than M-MDSCs. In vitro, PMN …

Jan 18, 2024 · Precise molecular characterization of circulating polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) is hampered by their mixed composition of mature …

May 29, 2019 · Our findings reveal a totally unexpected immunostimulatory role of adoptively transferred MDSCs in TxT and might offer options to interfere with post-traumatic malfunction …