Targeting the MDSCs of Tumors In Situ With Inhibitors of the MAPK ...
Mar 18, 2021 · In this study, we performed RNA sequencing of MDSCs derived from the spleen and tumor. Based on the results of our RNA-seq analysis, mitogen-activated protein kinases …
Signaling pathways involved in MDSC regulation - PMC
In this review we discuss the role played by key signaling pathways such as PI3K, Ras, Jak/Stat and TGFb during myeloid development and how their deregulation under pathological …
IL-6 Promotes the Proliferation and Immunosuppressive Function …
Apr 23, 2021 · In coculture analysis, MDSCs, with the stimulation of IL-6, could significantly lower the proliferation ability of CD4 + or CD8 + T lymphocytes. Further, this study demonstrated …
Myeloid-derived suppressor cells in the era of increasing ... - Nature
Feb 1, 2021 · Myeloid-derived suppressor cells (MDSCs) are pathologically activated neutrophils and monocytes with potent immunosuppressive activity. They are implicated in the regulation …
Exportin 1 governs the immunosuppressive functions of myeloid …
Jun 20, 2024 · We found that tumor MDSCs increase XPO1 expression through an IL-6-STAT3-dependent pathway. We showed that XPO1 blockade induces a shift in MDSC differentiation …
Targeting myeloid-derived suppressor cells in tumor …
Mechanistically, activated hematopoietic stem cell (HSC) induced monocyte-intrinsic p38 mitogen-activated protein kinase (MAPK) signaling to trigger enhancer reprogramming for M-MDSC …
Abnormal activation of NF-κB and MAPK signaling pathways …
Further analysis revealed that the activation of nuclear factor-kappa B (NF-κB) and mitogen-activated protein kinase (MAPK) pathways recruited a large number of MDSCs via cytokines. …
Myeloid-derived suppressor cells promote tumor growth and …
Apr 1, 2022 · MAPK pathway, one of the sorafenib targets, is the downstream signaling of FGF1 and is reactivated by MDSCs-mediated FGF1 upregulation. Our finding demonstrated that …
Targeting the MDSCs of Tumors In Situ With Inhibitors of the MAPK ...
In this study, we performed RNA sequencing of MDSCs derived from the spleen and tumor. Based on the results of our RNA-seq analysis, mitogen-activated protein kinases (MAPK) were …
CXCL2/MIF-CXCR2 signaling promotes the recruitment of …
Oct 10, 2016 · Studies have reported that mitogen-activated protein kinase (MAPK) and nuclear factor kappa B (NF-κB) regulate cytokine secretion in MDSCs. 20 To investigate the …