Methylenedioxypyrovalerone (abbreviated MDPV, and also called monkey dust[3]) is a stimulant of the cathinone class that acts as a norepinephrine–dopamine reuptake inhibitor (NDRI). [4][5] It was first developed in the 1960s by a team at Boehringer Ingelheim. [6] .

3,4-Methylenedioxypyrovalerone (MDPV) and its structural parent, α-pyrrolidinovalerophenone (α-PVP), are two of the best studied new synthetic cathinones. Unlike methcathinone and certain other cathinones, MDPV and α-PVP act primarily as reuptake inhibitors at dopamine and norepinephrine membrane transporters rather than as substrates.

In this chapter, we review the neuropharmacology of MDPV and related analogs, and supplement the discussion with new results from our preclinical experiments. MDPV acts as a potent uptake inhibitor at plasma membrane transporters for dopamine (DAT) and …

MDPV, or 3,4-Methylenedioxypyrovalerone, is a synthetic stimulant of the cathinone and pyrrolidine classes. MDPV is the 3,4-methylenedioxy ring-substituted analog of the compound a-PVP, developed in the 1960s, which has been used for the treatment of chronic fatigue and as an anorectic, but caused problems of abuse and dependence. [3]

3,4-Methylenedioxypyrovalerone (MDPV) (Fig. 1) is one of the best known of the synthetic cathinones and an original constituent of psychoactive “bath salts”. α-Pyrrolidinovalero-phenone (α-PVP or flakka), its structural parent, is currently …

Mar 11, 2025 · MDPV, or methylenedioxypyrovalerone, is a potent synthetic stimulant known for its powerful effects and potential for abuse. Associated with the “bath salts” phenomenon, MDPV poses significant health risks, making it crucial to understand its impact on users.

MDPV is a potent, synthetic euphoric stimulant with a short history of human use, which shares some empathogenic effects with MDMA. It is known for its tendency to cause compulsive redosing and some users report sexual arousal. MDPV has been found in products sold as "bath salts", "plant food/fertilizer", and in some cases "ecstasy".

Among the available synthetic cathinones in the United States, 3,4-methylenedioxypyrovalerone (MDPV) is commonly abused and associated with dangerous side effects. MDPV is a dopamine transporter blocker 10-fold more potent than cocaine as a locomotor stimulant in rats.

Two common ingredients of ‘bath salts’ include the cathinone analogs: mephedrone and methylenedioxy-pyrovalerone (MDPV). The mechanism of action of these synthetic cathinone analogs has not been well investigated.

3',4'-Methylenedioxy-α-pyrrolidinobutyrophenone (MDPBP) is a stimulant of the cathinone class developed in the 1960s, [1][2] which has been reported as a novel designer drug. [3][4] MDPBP is sometimes sold under the name "NRG-1" as a mixture with other cathinone derivatives, including flephedrone, pentylone, MαPPP and its higher homologue MDPV. ...