MALDI TOF mass spectrometer. In mass spectrometry, matrix-assisted laser desorption/ionization (MALDI) is an ionization technique that uses a laser energy-absorbing matrix to create ions from large molecules with minimal fragmentation. [1]

The study revealed that SARS-CoV-2 detection by PCR-MALDI-TOF MS had high accuracy, sensitivity, and specificity and could be used in clinical settings to improve SARS-CoV-2 nucleic acids testing efficiency.

Over the past decade, several studies have explored methods to conduct quantitative MSI (qMSI) that are robust, reproducible, and accurate. These methods, which will be discussed more in detail below, seek to minimize several fundamental aspects of ion suppression effects, sample heterogeneity, and analyte recovery.

This chapter describes the basic technology and application of matrix-assisted laser desorption ionization (MALDI) imaging mass spectrometry (MS) in the field of neurobiology. Examples of applications that search for biomarkers of diseases of the central nervous system for both diagnostic and prognostic purposes are discussed.

Matrix-assisted laser desorption ionization-time-of-flight mass spectrometry (MALDI-TOF MS) has been instrumental in revolutionizing microbiological identification, especially in high-throughput laboratories.

MALDI-TOF mass spectrometry is a versatile analytical technique to detect and characterize mixtures of organic molecules. In microbiology, it is used as a rapid, accurate, and cost-effective method for identifying microorganisms (bacteria, fungi, and viruses).

Jan 30, 2025 · An example study conducted by van Veen presents a comparative performance of identification using MALDI TOF MS and biochemical methods, in relation to 16S rRNA. This prospective study included 980 clinical isolates of bacteria and yeasts.

Aug 19, 2016 · This chapter reviews the history and the background of matrix assisted laser desorption ionization time of flight mass spectrometry (MALDI-ToF-MS) analysis. The chapter covers, application of this technique in variety of different areas with the special focus on...

2 days ago · This study aims to employ MALDI-TOF MS for identifying malaria by distinguishing P. falciparum-positive from P. falciparum-negative sera. Sera were obtained from 282 blood samples collected from non-febrile, asymptomatic people aged 5 to 58 years in southern Côte d’Ivoire. Infectious status and parasitaemia were determined by both RDTs and ...

4 days ago · The development of spatial multiomics technologies, particularly matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI), has revolutionized our ability to map metabolic processes at single-cell resolution. However, the current techniques face challenges in minimizing matrix interferences and achieving comprehensive metabolite detection across multiple ionization ...