Jul 3, 2018 · MYCMI-6 exhibits strong selective inhibition of MYC:MAX interaction in cells and in vitro at single-digit micromolar concentrations, as validated by split Gaussia luciferase, in situ …

Mar 31, 2022 · Our findings demonstrate that the small-molecule MYCMI-7 binds MYC and inhibits interaction between MYC and MAX, thereby hampering MYC-driven tumor cell growth …

Jul 1, 2012 · MYC-associated protein X (MAX) is a ubiquitous, constitutively expressed protein that plays a central role in controlling the MYC/MAX/MAX dimerization protein 1 (MXD1) axis, …

Nov 11, 2019 · We developed a series of small-molecule MYC inhibitors that engage MYC inside cells, disrupt MYC/MAX dimers, and impair MYC-driven gene expression. The compounds …

Oct 28, 2019 · Here, we demonstrate by both a p roximity l igation a ssay (PLA) and double chromatin immunoprecipitation (ReCHIP) that Omomyc preferentially binds to Max, not Myc, to …

May 27, 2020 · Titration shows an IC 50 for inhibition of MYC:MAX of less than 1.5 μM for MYCMI-6 by PLA. MYCMI-6 inhibits the MYC:MAX heterodimer formation with an IC 50 of 3.8 …

Using proximity ligation assay (PLA) and superresolution stochastic optical reconstruction microscopy (STORM) imaging, we found that pS62MYC associates with the basket of the NPC.

Mar 30, 2025 · After forming a heterodimer with its obligate partner Max, Myc binds consensus E-boxes ... (Fig. 1A) or PLA (Fig. 2C, Myc only) muscle were reverse transcribed using the …

May 27, 2020 · Titration shows an IC 50 for inhibition of MYC:MAX of less than 1.5 μM for MYCMI-6 by PLA. MYCMI-6 inhibits the MYC:MAX heterodimer formation with an IC 50 of 3.8 …

MYCMI-6 exhibits strong selective inhibition of MYC:MAX interaction in cells and in vitro at single-digit micromolar concentrations, as validated by split Gaussia luciferase, in situ proximity …