Identification of c-MYC as a target of the APC pathway
Sep 4, 1998 · The adenomatous polyposis coli gene (APC) is a tumor suppressor gene that is inactivated in most colorectal cancers. Mutations of APC cause aberrant accumulation of beta …
Anti-Myc tag APC antibody [9E10] (ab223896) Mouse monoclonal IgG1 - Abcam
Mouse Monoclonal C-Myc/MYC antibody - conjugated to APC. Suitable for Flow Cyt (Intra) and reacts with Tag samples.
Myc deletion rescues Apc deficiency in the small intestine | Nature
Mar 21, 2007 · Here we show that loss of Myc rescued the phenotypes of perturbed differentiation, migration, proliferation and apoptosis, which occur on deletion of Apc. …
Myc deletion rescues Apc deficiency in the small intestine
Apr 5, 2007 · The proto-oncogene c-MYC has been identified as a target of the Wnt pathway in colorectal cancer cells in vitro, in normal crypts in vivo and in intestinal epithelial cells acutely …
c-Myc Target Genes Involved in Cell Growth, Apoptosis, and Metabolism
The c- myc gene is a central oncogenic switch for oncogenes and the tumor suppressor APC. The APC tumor suppressor protein mediates the degradation of β-catenin.
C-Myc is a critical mediator of the phenotypes of Apc loss in …
Jul 1, 2008 · The Adenomatous polyposis coli (Apc) gene is mutated in up to 80% of sporadic colorectal cancers. After Apc loss, there is deregulation of the Wnt signaling pathway and …
Identification of c-MYC as a Target of the APC Pathway
Sep 4, 1998 · The adenomatous polyposis coli gene (APC) is a tumor suppressor gene that is inactivated in most colorectal cancers. Mutations of APC cause aberrant accumulation of β …
Role of c-Myc in Apc Mutant Intestinal Phenotype: Case Closed or …
May 8, 2007 · Inactivation of the adenomatous polyposis coli (APC) tumor suppressor gene occurs in most colorectal cancers. The proto-oncogene c-MYC was one of the first genes …
Regulation of MYC gene expression by aberrant Wnt/β-catenin …
Deregulated expression of the c-MYC proto-oncogene (MYC) by aberrant Wnt/β-catenin signaling drives colorectal carcinogenesis. In this review, we discuss the current literature pertaining to …
mTOR inhibition suppresses Myc-driven polyposis by inducing
May 3, 2023 · Myc is a key driver of colorectal cancer initiation and progression, but remains a difficult drug target. In this study, we show that mTOR inhibition potently suppresses intestinal …