Nov 30, 2017 · In a mouse lung model of KRas G12D -driven adenomas, we find that co-activation of Myc drives the immediate transition to highly proliferative and invasive adenocarcinomas marked by highly inflammatory, angiogenic, and immune-suppressed stroma.

Feb 13, 2017 · We show that Myc expression cooperates with Rb1 and Trp53 loss in the mouse lung to promote aggressive, highly metastatic tumors, that are initially sensitive to chemotherapy followed by relapse, similar to human SCLC.

Jul 13, 2017 · Although the posttranslational regulation of MYC can significantly contribute to RAS-driven cancer and to resistance to interventions targeting RAS signaling, many questions still remain. What MYC PTMs are necessary for MYC/RAS cooperation, and how are they regulated?

Genes (Basel). 2017 May 25;8 (6):151. doi: 10.3390/genes8060151. MYC regulates a complex biological program by transcriptionally activating and repressing its numerous target genes. As such, MYC is a master regulator of many processes, including cell cycle entry, ribosome biogenesis, and metabolism.

Myc is recognized as a “most wanted” target for cancer therapy, but has for many years been considered undruggable, mainly due to its nuclear localization, lack of a defined ligand binding site, and physiological function essential to the maintenance of normal tissues.

Aug 14, 2017 · The most extensively studied pathway regulating MYC protein stability involves ubiquitylation and proteasomal degradation mediated by the E3-ligase, SCFFbxw7.

May 8, 2017 · Here we examined the role of Myc activation in mouse liver tumours induced by hepatocytic expression of myristoylated AKT (AKT) and/or mutant HRASV12 (HRAS) via transposon-mediated gene...

Oct 3, 2017 · Altogether, our findings suggest that the innate role of MYC-mediated cell competition in development is conserved in human cancer, with malignant cells using MYC activity to colonise the organ at the expense of less performant neighbours.

Jul 5, 2022 · In a mouse lung model of KRasG12D-driven adenomas we find that co-activation of Myc drives the immediate transition to highly proliferative and invasive adenocarcinomas marked by highly...

Oct 3, 2017 · Herein, we demonstrate that MYC and MCL1 cooperate in the maintenance of chemotherapy-resistant cancer stem cells (CSCs) in TNBC. MYC and MCL1 increased mitochondrial oxidative phosphorylation (mtOXPHOS) and the generation of reactive oxygen species (ROS), processes involved in maintenance of CSCs.