Myc is a family of regulator genes and proto-oncogenes that code for transcription factors. The Myc family consists of three related human genes: c-myc (MYC), l-myc (MYCL), and n-myc …

MYC is a master regulator of multiple biological programmes and mediates much of its function primarily as a transcription factor that regulates the expression of thousands of genes, either …

The MYC oncogene encodes a transcription factor, MYC, whose broad effects make its precise oncogenic role enigmatically elusive. The evidence to date suggests that MYC triggers …

We present a view of MYC as a sensor that integrates multiple cellular signals to mediate a broad transcriptional response controlling many aspects of cell behavior. We also describe the larger …

Aug 9, 2021 · In this review, MYC regulation and the mechanisms by which MYC adjusts cellular functions and its implication in hematologic malignancies are summarized. Further, we also …

Aug 10, 2022 · As an oncogenic driver, MYC amplifies global transcription by driving pause release and the early transcription, especially of highly expressed genes. It stimulates …

Members of the MYC family of proto-oncogenes are the most commonly deregulated genes in all human cancers. MYC proteins drive an increase in cellular proliferation and facilitate multiple …

Myc, a transcription factor encoded by the MYC proto-oncogene, is a key regulator of G1–S progression and plays a direct role in the control of DNA replication. Myc is broadly expressed …

Oct 24, 2023 · MYC, a key member of the Myc-proto-oncogene family, is a universal transcription amplifier that regulates almost every physiological process in a cell including cell cycle, …

Jan 30, 2023 · Deregulated expression of the transcription factor MYC is a crucial event in a wide variety of cancer cells. Deregulation—usually due to overexpression—affects transcriptional …