MUC1 stimulates EGFR expression and function in endometrial …
May 31, 2016 · We show for the first time that MUC1 stimulates EGFR expression and function in endometrial cancer. siRNA knockdown and CRISPR/Cas knockout of MUC1 reduced EGFR …
MUC1 induces acquired chemoresistance by upregulating ABCB1 in EGFR ...
Aug 10, 2017 · Through stimulation of EGFR activation and nuclear translocation, MUC1 increased the expression of ATP-binding cassette transporter B1 (ABCB1). Remarkably, …
EGFR and MUC1 as dual-TAA drug targets for lung cancer and
Nov 27, 2024 · Results: A candidate TAA target, transmembrane glycoprotein mucin 1 (MUC1), showed strong expression in cancer cells and low expression in normal cells. Single-cell …
Abstract 6325: A novel EGFR x MUC1 bispecific antibody-drug …
Apr 4, 2023 · Epidermal growth factor receptor (EGFR) and mucin 1 (MUC1) are tumor-associated antigens that are highly co-expressed in esophageal squamous cell carcinomas, …
Interaction of galectin-3 with MUC1 on cell surface promotes EGFR ...
Jul 21, 2017 · EGFR is associated in epithelial cells with the heavily glycosylated transmembrane mucin protein MUC1, a natural ligand of galectin-3 that is overexpressed in cancer. This study …
MUC1-EGFR crosstalk with IL-6 by activating NF-κB and MAPK …
In vitro experiments have confirmed that MUC1 affects cancer cell stemness through the MUC1-EGFR-IL-6 pathway, characterized by a significant decrease in the expression of IL-6 and …
Quantitative proteomics analysis identifies MUC1 as an effect …
Oct 10, 2018 · Using a proteomics approach to identify effect sensors, we demonstrated MUC1 upregulation in response to epidermal growth factor receptor (EGFR)-targeting treatments in …
Activated EGFR stimulates MUC1 expression in human uterine …
In this study, we demonstrate that activated EGFR drives high level MUC1 expression in multiple cell lines of uterine adenocarcinoma and pancreatic cancer origins. In some cells, addition of …
MUC1 regulates AKT signaling pathway by upregulating EGFR …
Aug 1, 2021 · In our study, we have observed that MUC1 can play a crucial role in the development and progression of ovarian cancer and act as a predictive marker. We also found …
MUC1 stimulates EGFR expression and function in endometrial …
We show for the first time that MUC1 stimulates EGFR expression and function in endometrial cancer. siRNA knockdown and CRISPR/Cas knockout of MUC1 reduced EGFR gene …
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