Role of the MUC1-C oncoprotein in the acquisition of cisplatin ...
We aimed to elucidate the molecular mechanisms underlying the acquisition of cisplatin (CDDP) resistance through MUC1-C oncoprotein in UC cells. MUC1-C expression was examined …
MUC1-C IS A DRUGGABLE TARGET FOR TREATMENT OF
MUC1-C thereby drives proinflammatory NF-κB pathway genes in human inflamed UC tissues and in the genetically engineered mouse model (GEMM) of colitis. Mechanistically, MUC1-C …
MUC1-C ACTIVATES THE TAK1 INFLAMMATORY PATHWAY IN …
MUC1-C promotes NF-κB-mediated induction of TAK1 transcription by interacting with NF-κB p65 on the TAK1 promoter and increasing NF-κB occupancy. MUC1-C also forms a complex with …
Expression of MUC1 in different tumours and its clinical …
Mucin 1 (MUC1) was the first discovered transmembrane protein of the mucin family; it normally covers epithelial cells of the mucous membrane, providing lubrication and protection. …
MUC1: An emerging target in cancer treatment and diagnosis
Sep 1, 2022 · Mucin 1 C‐terminal subunit (MUC1‐C) has been introduced as a key regulator for acquiring drug resistance in various cancers, but the functional role of MUC1‐C of urothelial …
Muc1: a multifaceted oncoprotein with a key role in cancer …
The transmembrane glycoprotein Mucin 1 (MUC1) is aberrantly glycosylated and overexpressed in a variety of epithelial cancers, and plays a crucial role in progression of the disease. Tumor …
A Mucin1 C-terminal Subunit-directed Monoclonal Antibody …
Jan 1, 2018 · Results: The anti-hMUC1 antibody recognized recombinant MUC1 as well as native MUC1-C protein in breast cancer cells. Anti-hMUC1 binds to the membrane surface of cells …
Mucin-1 - Wikipedia
Mucin-1 (MUC-1) is a heterodimer transmembrane protein of the mucin family encoded in humans by the MUC1 gene. [3][4][5] It is cleaved into two chains: mucin-1 subunit alpha (MUC1-NT; …
MUC1: Structure, Function, and Clinic Application in ... - PubMed
Jun 18, 2021 · The transmembrane glycoprotein mucin 1 (MUC1) is a mucin family member that has different functions in normal and cancer cells. Owing to its structural and biochemical …
Role of the MUC1‐C oncoprotein in the acquisition of cisplatin ...
Jul 16, 2020 · We aimed to elucidate the molecular mechanisms underlying the acquisition of cisplatin (CDDP) resistance through MUC1-C oncoprotein in UC cells. MUC1-C expression …
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