In cancer cells, MUC1 participates in intracellular signal transduction pathways and regulates the expression of its target genes at both the transcriptional and post-transcriptional levels. This …

Among them, Mucin 1 (MUC1) is widely studied for its role in the pathogenesis of various cancer types, and it is the most intensively studied transmembrane protein of the mucin family. In …

This review introduces the biological structure and different roles of MUC1 in normal and cancer cells and the regulatory mechanisms governing these roles. It also evaluates current research …

Jun 18, 2021 · This review introduces the biological structure and different roles of MUC1 in normal and cancer cells and the regulatory mechanisms governing these roles. It also …

This review highlights the structural and functional differences that exist between normal and tumor-associated MUC1. We also discuss the recent advances made in the use of MUC1 as a …

Oct 8, 1999 · Immune responses to MUC1 have been seen in breast and ovarian cancer patients and clinical studies have been initiated to evaluate the use of antibodies to MUC1 and of …

Nov 1, 2022 · MUC1 is a highly glycosylated transmembrane mucin on the luminal surface of epithelial cells, protecting them from extreme factors. In cancer cells, MUC1 expression is …

4 days ago · As proof, MUC1 in cancer is proven to express a variety of simple and short sugar chain antigens such as Tn, sialyl-Tn, and sialyl-Lewis-X, emerging targets for cancer diagnosis …

Based on these findings, a first-in-class MUC1-C inhibitor has entered Phase I evaluation as a potential agent for the treatment of patients with breast cancers that express this oncoprotein. …

Mar 22, 2014 · MUC1 promotes growth, metastasis, and resistance to drugs in cancer. In tumors, the cytoplasmic tail of MUC1 acts as an oncogenic signaling molecule. MUC1 regulates gene …