MPP1 is more similar to the previously defined IT-HSC or ST-HSC, which have multiple-lineage reconstitution ability up to 4 months in the first transplantation, whereas MPP2/3/4 are devoid of self-renewal potential and only exhibit short-term myeloid reconstitution ability (<1 month).

Jun 10, 2021 · In this study, together with the already reported characterization of MPP1-4, we functionally characterize MPP5 and MPP6 and provide the transcriptomic landscapes of MPP1-5, further refining the definition of progenitor populations downstream of HSCs within the …

In this study, we applied single-cell RNA sequencing (scRNA-seq) and established an integral transcriptional landscape of human bone-marrow-derived HSPCs temporally from birth through to the aging stage (neonate, infant, child, adult, and aging) in 11 individuals.

Oct 1, 2021 · Yet, whether AHR modulates HSPC lineage potential and directs differentiation toward specific lineage-biased progenitors is not well understood. This study revealed that AHR KO mice have an increased proportion of myeloid-biased HSCs and myeloid-biased multipotent progenitor (MPP3) cells.

May 16, 2022 · To investigate the intrinsic changes in hematopoietic stem and progenitor cells (HSPCs) during aging, we purified HSCs, multipotent progenitor (MPP) 1, megakaryocyte/erythroid-biased MPP2,...

Aug 2, 2021 · Limited knowledge of cellular and molecular mechanisms underlying hematopoietic stem cell and multipotent progenitor (HSC/MPP) expansion within their native niche has impeded the application of...

We investigated the role of MED12 in hematopoietic stem and progenitor cells (HSPCs) in vivo using several hematopoieticspecific Med12 knockout animal models. We show that MED12 is essential for HSC homeostasis as Med12 deletion led …

In this study, we applied single-cell RNA sequencing (scRNA-seq) and established an integral transcriptional landscape of human bone-marrow-derived HSPCs temporally from birth through to the aging stage (neonate, infant, child, adult, and ag-ing) in 11 individuals.

Mar 23, 2023 · MPP1, similar to IT- and ST-HSCs, are capable of self-renewal and restoration of hematopoiesis for a period of approximately 4 months after transplantation and are characterized by the LSK CD150 + Flk2-CD48 – phenotype.

Sep 26, 2011 · Leukocytosis is associated with the proliferation of hematopoietic stem and multipotential progenitor cells (HSPCs) in mice with deficiencies of the cholesterol efflux–promoting ABC transporters ABCA1 and ABCG1 in BM cells. Here, we have determined the role of endogenous apolipoprotein-mediated cholesterol efflux pathways in these processes.