Dec 21, 2023 · MMP is a key gene associated with cancer disease progression, invasion, metastasis, and avoidance of immune surveillance and is frequently upregulated in cancer. ITGB6-mediated MMP expression enhances tumor invasiveness .

Jul 2, 2020 · In this study, we firstly established a cell model of ITGB1 inhibition or overexpression in LS174T cells, and found that inhibition of ITGB1 could enhance the inhibition effect of cetuximab on proliferation of cancer cells.

Mar 4, 2014 · The overexpression of the matrix extracellular genes ITGA-3 and ITGB-5 is associated with advanced stage tumors, and the genes MMP-2 and MMP-9 are overexpressed in mucinous and villous adenocarcinoma type tumors, respectively.

Jan 4, 2024 · For the present study, we explored the role of MEK/MAPK and ITGB1 levels contributing to osimertinib resistance in EGFR mutant NSCLCs and we assessed whether such resistance may be related to the...

May 17, 2016 · The increased regional and distant metastasis observed in HER 2+ tumors with high levels of ITGB 6 might be mediated by the canonical Rho–Rac pathway through increased expression of MMP 9 and MMP15.

Mar 4, 2014 · This investigation intended to evaluate the association between FN-1, ITGA-3, ITGB-5, MMP-2, and MMP-9 gene and protein expression levels in tumor tissue with clinical and histopathological neoplastic parameters of cancer dissemination.

Feb 8, 2025 · Our comprehensive analysis of the molecular landscape surrounding the trauma in TBI mice has revealed a significant alteration in the abundance of β2 integrin (ITGB2), predominantly expressed by neutrophils and closely associated with immune responses.

MAPK activity and cross-signaling between Mmp14, Erk and Itgb1 are involved in branching morphogenesis. (A) Silencing Mmp14 reduces Erk activity and the level of Itgb1. (i) Immunoblots of...

Nov 27, 2022 · Expression of the SMAD-6 gene was significantly increased and the expression of the LOX, CAV-1, PLG, ITGA-2, MMP-1, and CTGF genes was significantly decreased in CHC patients compared to controls (Figure 1, Table 2).

Jan 15, 2025 · Matrix metalloproteinases (MMPs) control the complex processes of morphogenesis and tissue remodelling. They are important for both homeostatic and developmental processes, and play a role in regulation. The MMPs participants in the pathophysiology of many illnesses, such as ECM disruption and tissue remodelling caused by dysregulated MMP activity.