In this review, we discuss modes of regulation of IL-10 gene expression in immune effector cell types, including signal transduction, epigenetics, promoter architecture, and post-transcriptional regulation, and how aberrant regulation contributes to immunopathology and disease progression.

Feb 1, 2016 · MK2 is critical for MCMV-induced production of IL-10, IFN-α2 and 4, IFN-β, IL-6, and TNF-α but not for IFN-γ. The MCMV-induced IL-10 production requires activation of IFNAR1 and is further regulated by MK2 and TTP-dependent stabilization of IL-10 transcripts.

The data suggest that MK2 is critical for regulating cytokine responses towards acute MCMV infection, including that of IL-10 via IFNARI-mediated circuits. MCMV stimulates expression of MK2-dependent cytokines, in particular IL-10 and thereby prevents enhanced formation of intrahepatic iMATE-like ce …

Inhibition of TNF translation by IL‐10 is exerted mainly by inhibition of the activating p38/MAPK‐activated protein kinase‐2 pathway. These results demonstrate a physiologically significant cross‐talk between the IL‐10 receptor and the stress‐activated protein kinase modules targeting TNF mRNA translation.

Dec 21, 2022 · The IL-10 gene locus is located 36 kb upstream of the MK2 (MAPK-activated protein kinase 2 [MAPKAPK2]) gene, which is a critical component of the p38-MAPK signaling pathway (Fig. 5A). MK2 is required for IL-10 production and is …

We began by resequencing 48 European and 48 African chromosomes across 2.2 kb of the IL10 promoter region, and compared this with four neighbouring gene regions: MK2, IL19, IL20 and IL24. Analysis of nucleotide diversity showed a positive Tajima's D-test for IL10 in Europeans, of borderline statistical significance (1.89, P=0.05).

Here, we report that PKM2 activation with the pharmacological agent TEPP-46 increases IL-10 production in LPS-activated macrophages by metabolic reprogramming, leading to the production and release of ATP from glycolysis. The effect of TEPP …

MK2 is known to regulate inflammatory cytokine expression on a post-transcriptional level suggesting a similar role of MK2 for sta-bilization of the virus-induced IL-10 transcript.

Jul 7, 2001 · We show here that the development of chronic intestinal inflammation in IL-10-deficient mice requires the function of TNF, indicating that the IL-10/TNF axis regulates mucosal immunity. We further show that IL-10 targets the 3′ AU-rich elements (ARE) of TNF mRNA to inhibit its translation.

Aug 31, 2006 · We began by resequencing 48 European and 48 African chromosomes across 2.2 kb of the IL10 promoter region, and compared this with four neighbouring gene regions: MK2, IL19, IL20 and IL24.