Jul 1, 2021 · Anti-MDA5 antibodies and anti-Ro52 antibodies were detected in immunoblotting and semi-quantitatively analysed by densitometry. Clinical features and the 24 month survival were compared between anti-MDA5-positive patients with and without anti-Ro52 antibodies.

Feb 1, 2023 · Notably, in patients with anti-MDA5+ DM, the coexistence of anti-MDA5 and anti-Ro52, compared to patients without anti-Ro52, conferred a nearly 4-fold higher incidence of RP-ILD (48.7% vs 12.5%) and a 2-fold increased mortality rate (29.1% vs 15.9%).

Anti-Ro52 antibodies were highly prevalent in patients with anti-MDA5+ DM, and their coexistence correlated with a higher rate of RP-ILD and mortality. Patients with a short disease course, with increased inflammation, and without rash were more likely to have a poor prognosis.

Jul 24, 2023 · Rapidly progressive interstitial lung disease, anti-Ro52 antibody levels, and age > 57 years are possible predictors of mortality risk in patients with anti-MDA5 dermatomyositis.

We established the STRAD-Ro52 model using the presence of anti-Ro52 antibody and S6%V7, which can predict the risk of severe ILD in MDA5 + DM-ILD within six months. Several studies have proposed risk-prediction models for the prognosis of MDA5 + DM-ILD.

Feb 1, 2023 · Coexistence of anti-Ro52 antibodies in anti-MDA5 antibody-positive dermatomyositis is highly associated with rapidly progressive interstitial lung disease and mortality risk. J Rheumatol 2023; 50: 219-26.

Nov 2, 2022 · Anti-Ro52 antibodies were highly prevalent in patients with anti-MDA5 and anti-Jo1 antibodies. Within all patients with IIM-ILD, those with anti-Ro52 autoantibodies had a higher frequency of RP-ILD and a poorer prognosis, especially in the anti-MDA5 antibody subgroup.

In particular cases, the coexistence of anti-Ro52 and anti-MDA5 antibodies has been associated with aggressive and rapidly progressive ILD in anti-MDA5 syndrome (53, 54) but there are conflicting data on the prognostic role of anti-Ro52 antibodies when …

Relevant examinations revealed elevated levels of muscle enzyme, double‐positive anti‐MDA5 and anti‐SSA/Ro52 antibodies, positive rheumatoid factor, and a high titer of anti‐citrullinated protein antibody. DM overlapping rheumatoid arthritis with ILD was confirmed.

May 16, 2024 · Anti-Ro52 antibody, known as tripartite motif-containing protein 21 (TRIM21) antibody, has been reported on the association of rapidly progressive interstitial lung disease (RP-ILD) with anti-MDA5 + DM . This report discusses a case characterised by co-positive of anti-MDA5 and anti-Ro52 antibodies.