In addition to classic rashes of DM that occur in 60–70%, patients with anti-MDA5 DM may manifest cutaneous features suggestive of an underlying vasculopathy, such as cutaneous ulcers and palmar papules.

Melanoma differentiation-associated gene 5 (MDA5)-positive dermatomyositis (DM) is a rare systemic autoimmune disease associated with a high rate of mortality attributable to rapidly progressive interstitial lung disease. MDA5-positive DM is often complicated by a typical rash and muscle weakness.

Dec 6, 2023 · Distinctive skin rashes, rapidly progressive interstitial lung disease, peripheral lymphopenia and elevated serum ferritin levels are the most prominent clinical and...

The most common skin findings in anti-MDA5 DM include skin ulceration, mechanic’s hands, palmar papules, heliotrope rash, Gottron’s papules and periungual erythema; the most severe ones being the ulceration which can lead to gangrene, osteomyelitis and eventually to digital amputation [19,20,21].

Mar 4, 2024 · Dermatomyositis (dur-muh-toe-my-uh-SY-tis) is an uncommon inflammatory disease marked by muscle weakness and a distinctive skin rash. The condition can affect adults and children. In adults, dermatomyositis usually occurs in the late 40s to early 60s.

Anti-Melanoma Differentiation-Associated gene 5 (MDA-5) Dermatomyositis (MDA5, DM) is a recently identified subtype of myositis characteristically associated with Rapidly Progressive Interstitial Lung Disease (RP-ILD) and unique cutaneous features.

May 9, 2024 · Regarding symptoms specifically present at the time of diag-nosis, a vast majority (93%) reported active skin issues such as rashes or itching. Subjective muscle weakness (74%), pain (72%), cutaneous and oral ulcerations (58%), and arthritis (56%) were the next most common symptoms to be present.

May 25, 2021 · Features of anti-MDA5 DM include cutaneous ulcerations, most commonly overlying Gottron papules on the elbows and digits, as well as painful palmar macules and papules. We describe 2 patients with anti-MDA5 DM who presented with an …

Sep 9, 2023 · A 46-year-old woman presented with shortness of breath, dry cough, and painful rash on the upper arms. Examination was notable for erythematous lesions on the lateral upper arms and ventral...

Oct 10, 2023 · Upon review of symptoms, he reported 35-pound unintentional weight loss, dry mouth, rashes on his back and chest as well as swollen digits. His exam revealed bibasilar crackles, Shawl sign, Raynaud's phenomenon, and calcinosis on his arm.