Anti-melanoma differentiation-associated gene 5-positive dermatomyositis (MDA5 + DM) is a rare autoimmune disease predominantly reported in East Asia. MDA5 + DM is an intractable disease with impressively high mortality due to rapid-progressive interstitial lung disease (RPILD).

Anti-Melanoma Differentiation-Associated gene 5 (MDA-5) Dermatomyositis (MDA5, DM) is a recently identified subtype of myositis characteristically associated with Rapidly Progressive Interstitial Lung Disease (RP-ILD) and unique cutaneous features.

Interstitial lung disease (ILD) is a major cause of morbidity and mortality in dermatomyositis (DM) and polymyositis (PM). The histopathologic findings of ILD in DM and PM include nonspecific interstitial pneumonia, usual interstitial pneumonia, organizing pneumonia, and …

The presence of autoantibodies against Melanoma Differentiation-Associated protein 5 (MDA5) in this group is highly associated with rapidly progressive interstitial lung disease (RP-ILD) and a worse prognosis.

Feb 28, 2024 · Anti-melanoma differentiation-associated gene 5 (MDA-5) dermatomyositis (DM) is noteworthy for its association with rapidly progressive interstitial lung disease (RP-ILD), vasculopathy, and distinctive cutaneous features.

Nov 3, 2023 · Anti-MDA5 (Melanoma differentiation-associated protein-5) positive dermatomyositis (MDA5 +-DM) is characterised by rapidly progressive interstitial lung disease (ILD) and high mortality. MDA5 is an RNA sensor and a key pattern recognition receptor for the SARS-CoV-2 virus.

Jul 17, 2019 · Anti–melanoma differentiation–associated protein (MDA) 5 (anti-MDA5)–positive amyopathic dermatomyositis (ADM)–associated interstitial lung disease (ILD) (hereafter, ADM-ILD) is a rapidly...

Establishing an accurate timeline between MDA5 antibody-positive DM and ILD can promote urgency among dermatologists to evaluate extracutaneous manifestations in their management of patients with DM for more accurate risk stratification and appropriate treatment.

We highlight the association with ILD, including four cases with definite or possible rp-ILD, requiring a regimen of potent, multi-agent immunosuppression to achieve remission. Cases. Demographic details, relevant initial investigations and a summary of the treatment agents used and current disease status is provided in Table 1. Anti-MDA-5 ...

Interstitial lung disease (ILD) is a serious and frequently fatal complication observed in patients with anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis (anti-MDA5+DM); however, the full clinical, radiological and pathological characteristics remain unclear.