Mar 30, 2025 · MCM3 (Minichromosome Maintenance Complex Component 3) is a Protein Coding gene. Diseases associated with MCM3 include Bone Disease and Anaplastic Astrocytoma. Among its related pathways are Activation of the pre-replicative complex and CDK-mediated phosphorylation and removal of Cdc6.

DNA replication licensing factor MCM3 is a protein that in humans is encoded by the MCM3 gene. [5] The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication.

Nov 27, 2024 · Here we characterize human double hexamer (hDH) loading using biochemical reconstitution and cryo-electron microscopy with purified proteins.

Mar 2, 2021 · Through exome and chromium genome sequencing, supported by functional studies, we identify biallelic pathogenic variants in MCM7 and a strong candidate biallelic pathogenic variant in MCM3.

Jan 4, 2021 · Our study reveals a coordinated signaling network centered around MCM3 that limits response to endocrine therapy in ER + breast cancer and identifies MCM3 as a clinically useful prognostic and...

Tubo-ovarian high-grade serous carcinomas (HGSC) are highly proliferative neoplasms that generally respond well to platinum/taxane chemotherapy. We recently identified minichromosome maintenance complex component 3 (MCM3), which is involved in the initiation of DNA replication and proliferation, as …

Mar 5, 2024 · Title: MCM3 is a novel proliferation marker associated with longer survival for patients with tubo-ovarian high-grade serous carcinoma. MCM complex members MCM3 and MCM7 are associated with a phenotypic spectrum from Meier-Gorlin syndrome to lipodystrophy and adrenal insufficiency.

Aug 17, 2024 · MCM3 is a novel proliferation marker associated with longer survival for patients with tubo-ovarian high-grade serous carcinoma.

The present study sought to evaluate and compare the immunoexpression of proteins minichromosome maintenance (MCM) 3 and Ki-67 in oral squamous cell carcinoma (OSCC) to assess the potential of these proteins as markers of cellular proliferation.

Early fractionation of eukaryotic MCM proteins yielded a variety of dimeric, trimeric and tetrameric complexes with unclear biological significance. The MCM2-7 hexamer is the proposed physiological active complex. This reaction proceeds in …