Hence, in this study we aimed to assess the association of baseline serum granzyme B, as well as germline variation of the GZMB gene, with clinical outcome to programmed cell death protein 1 (PD-1) blockade.

First, increased levels of Gzms have been found in the serum (GzmB), plasma (GzmA, GzmB), synovial fluid (GzmB, GzmM), and synovial tissue (GzmK) of patients with RA. Moreover, Gzms may contribute to inflammation by degrading the extracellular matrix …

Mar 10, 2022 · In this manuscript, we detailed the latest reports describing the control of IL-10, TGFβ, and GZMB production in different Breg subsets at the molecular level.

Nov 2, 2023 · RNA-seq analysis showed that the DEGs between KHYG1 with short-term re-expression of PRDM1 and control cells overlapped with DEGs between PRDM1 KO vs WT NK-cells. These genes included BCL11B, MAF, PRF1, and GZMB. Therefore, PRDM1 directly regulates genes that are crucial in NK-cell differentiation.

In the presence of MAF-CM, activated/non-naïve CTLs displayed dysregulated ERK1/2 and NF-κB signaling, impeded CD69 and granzyme B production, impaired killing activity, and upregulated expression of the negative immune checkpoint receptors TIGIT and BTLA.

Mar 11, 2022 · In this manuscript, we detailed the latest reports describing the control of IL-10, TGFb, and GZMB production in different Breg subsets at the molecular level.

Apr 8, 2024 · Primary GC in a TCGA stomach cancer dataset was evaluated for signature expressions, and a log-rank test determined overall survival (OS) and the disease-free interval (DFI). In 341 TCGA GC entries, high M2 TS expression was associated with histological types and later stages.

Jul 2, 2015 · Using Maf‐deleted CD8 T cells, our data show the partial dependence on Maf of the TGFβ inhibitory effects on naïve CD8 T‐cell proliferation, IL‐2 production, and Gzmb expression in response to antigen.

Jun 1, 2020 · Inconsistence in Gzmb and Maf expression might result from the difference between human Th17/1 cells and mouse pathogenic Th17 cells. In addition, as Th17/1 cell differentiation was enhanced by the exposure to IL-23, the elevated percentage of Th17/1 cells and the enhanced molecular signature of Th17/1 cells revealed an increased secretion of ...

Super-enhancer profiling identified novel genes that func-tionally specify the CD56dimand CD56brightsubsets, including G-coupled protein receptors (G-PCRs), which may modulate human NK function in response to tissue-derived factors.