Mar 15, 2017 · Here we report that methylation at the 6 position of adenosine (m6A) in RNA is rapidly (within 2 min) and transiently induced at DNA damage sites in response to ultraviolet irradiation.

Mar 23, 2017 · Here we report that methylation at the 6 position of adenosine (m 6 A) in RNA is rapidly (within 2 min) and transiently induced at DNA damage sites in response to ultraviolet irradiation.

Our results now demonstrate that methylation of poly (A) + RNA occurs in response to UV irradiation, suggesting an unprecedented RNA-mediated response to DNA damage. We next identified the enzymes responsible for regulating RNA methylation.

Apr 25, 2024 · The profound role of m6A modification in facilitating the response and repair of UV-induced DNA damage has been comprehensively explored. 48 Compelling research indicates that m6A is not only induced by UV irradiation, but also selectively recruited to UV-damaged sites to accelerate DNA repair and heighten cell resistance to UV damage.

In this review, we summarize the recent advances in the regulation and function of m 6 A RNA methylation, with a focus on UV-induced DNA damage response and the circadian clock machinery.

Feb 2, 2023 · In this review, Sendinc and Shi discuss the recent appreciation of nuclear roles for m6A in regulating chromatin states and gene expression, as well as the recent discoveries of the evolutionarily conserved methyltransferases, which catalyze methylation of adenosine on …

Apr 5, 2017 · Ultraviolet (UV) irradiation caused rapid and transient methylation at the 6 position of adenosine (m 6 A), predominantly in 5′ untranslated regions of poly (A) + RNA, including in transcripts...

The m6A demethylase FTO was decreased in both HaCaT cells and mouse skin after UV damage. Overexpressing FTO could improve cell viability, inhibit apoptosis and decrease RNA-m6A methylation, including LPCAT3-m6A, which increase LPCAT3 expression, cell viability promotion and apoptosis inhibition.

May 18, 2017 · Recently, Yang Xiang and colleagues have reported a novel role for RNA methylation (m6A) in the ultraviolet-induced DNA damage response. Here we’ll summarize how this RNA epigenetic mark serves as a signal in the DDR.

Apr 30, 2017 · Major finding: m 6 A RNA methylation rapidly recruits Pol κ to UV-induced damage sites to facilitate DNA repair. Concept: UV damage–induced m 6 A methylation of poly (A) + transcripts is added by METTL3 and removed by FTO. Impact: An RNA-mediated response to UV-induced DNA damage promotes rapid DNA repair and cell survival.