- N 6 -methyladenosine (m 6 A) is the most common, abundant, and conserved internal transcriptional modification in eukaryotes, and it is closely related to various biological functions, and plays vital roles in cells [1, 2]. m 6 A is a key regulatory mechanism that controls gene expression, and has been identified in many organisms, including mammals [1], yeast [3], and plants [4].Learn more:N 6 -methyladenosine (m 6 A) is the most common, abundant, and conserved internal transcriptional modification in eukaryotes, and it is closely related to various biological functions, and plays vital roles in cells [1, 2]. m 6 A is a key regulatory mechanism that controls gene expression, and has been identified in many organisms, including mammals [1], yeast [3], and plants [4].genomebiology.biomedcentral.com/articles/10.118…N6 -Methyladenosine (m6A), the most abundant internal modification associated with eukaryotic mRNAs, has emerged as a dynamic regulatory mechanism controlling the expression of genes involved in many physiological activities by affecting various steps of mRNA metabolism, including splicing, export, translation, and stability.cancerci.biomedcentral.com/articles/10.1186/s129…Modifications in RNA, such as N6-methyladenosine (m6A), are crucial for regulating gene expression and maintaining cellular health. m6A is the most prevalent internal modification on messenger RNA (mRNA) and has significant implications for various biological processes.biologyinsights.com/m6a-impact-on-rna-stability-spl…See more
The role of m6A modification in the biological functions and
Feb 21, 2021 · N 6 -methyladenosine (m6A) is the most prevalent, abundant and conserved internal cotranscriptional modification in eukaryotic RNAs, especially within higher eukaryotic cells. m6A modification is...
- Author: Xiulin Jiang, Xiulin Jiang, Baiyang Liu, Baiyang Liu, Zhi Nie, Zhi Nie, Zhi Nie, Lincan Duan, Qiuxia...
- Publish Year: 2021
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Genetic drivers of m6A me…
Analysis of 129 N6-methyladenosine (m6A) profiles across 4 tissues (brain, lung, …
m6 A RNA methylation: from mechanisms to therapeutic potential
Feb 1, 2021 · Here, we review current knowledge on the mechanisms by which m 6 A exerts its functions and discuss recent advances that underscore the multifaceted role of m 6 A in the …
- Author: P Cody He, P Cody He, Chuan He, Chuan He
- Publish Year: 2021
m6A RNA methylation: from mechanisms to therapeutic potential
Here, we review current knowledge on the mechanisms by which m 6 A exerts its functions and discuss recent advances that underscore the multifaceted role of m 6 A in the regulation of …
The role of m6A modification in the biological functions and
Feb 21, 2021 · N 6 -methyladenosine (m6A) is the most prevalent, abundant and conserved internal cotranscriptional modification in eukaryotic RNAs, especially within higher eukaryotic …
- Author: Xiulin Jiang, Xiulin Jiang, Baiyang Liu, Baiyang Liu, Zhi Nie, Zhi Nie, Zhi Nie, Lincan Duan, Qiuxia...
- Publish Year: 2021
mRNA m6A regulates gene expression via H3K4me3 shift in 5’ UTR …
Mar 12, 2025 · We demonstrate that m6A methylation in the 5’ UTR of mRNA triggers a downstream shift in H3K4me3 modification. This regulatory mechanism is conserved in …
Genetic drivers of m6A methylation in human brain, lung, heart …
Jul 1, 2021 · Analysis of 129 N6-methyladenosine (m6A) profiles across 4 tissues (brain, lung, muscle and heart) identifies 8,843 tissue-specific and 469 tissue-shared m6A quantitative trait …
Dynamic regulation and functions of mRNA m6A modification
Jan 29, 2022 · Here, we review the general role of m6A, highlighting recent advances related to the three major types enzymes that determine the level of m6A modification (i.e., writers, …
Genetic variants in m6A regulator genes confer …
2 days ago · Gene expression levels in both HCC and para-tumor tissues from the GEO database were analyzed using the R programming language and the GEO2R online tool. Specifically, the transcriptomic data from HCC cohorts …
m6A-express: uncovering complex and condition-specific m6A
Nov 18, 2021 · Here we develop m6A-express, the first algorithm for predicting condition-specific m6A regulation of gene expression (m6A-reg-exp) from limited methylated RNA …
m6A: Impact on RNA Stability, Splicing, and Cellular Health
Feb 8, 2025 · m6A modifications have profound effects on RNA stability and splicing, fundamental to gene expression regulation. m6A marks influence RNA half-life and degradation pathways, …
