Jan 11, 2019 · The crystal structure of CAPAM in complex with substrates revealed the molecular basis of cap-specific m 6 A formation. A transcriptome-wide analysis revealed that N 6 …

The first indication that m 6 A facilitates cap-independent translation came from the discovery that m 6 A residues in 5’UTRs enable ribosome loading and start site recognition on synthetic …

Nov 5, 2015 · Inhibition of adenosine methylation selectively reduces translation of mRNAs containing 5'UTR m(6)A. Additionally, increased m(6)A levels in the Hsp70 mRNA regulate its …

Nov 22, 2018 · CAPAM contains a unique structure that recognizes cap-specific N6 -methyladenosine (m 6 A) as the substrate. The protein interacts with RNA polymerase II, …

Oct 11, 2021 · Phosphorylated C-terminal domain (CTD)-interacting factor 1 (PCIF1) is a novel cap-specific adenine N6-methyltransferase responsible for m6Am formation. As PCIF1 …

Feb 2, 2023 · In this review, Sendinc and Shi discuss the recent appreciation of nuclear roles for m6A in regulating chromatin states and gene expression, as well as the recent discoveries of …

Jul 29, 2021 · In this chapter, we discuss the epitranscriptomic regulation of mRNA in general and focus on m 7 G cap-adjacent m 6 Am in particular. m 6 Am positions can now be distinguished …

m 6 A (red circle) regulates transcription, alternative splicing, alternative polyadenylation, nuclear export, cap‐dependent and cap‐independent translation, mRNA degradation, and mRNA …

in the early 1970s, m6A in mRNA from mammalian cells was identified and reported.8,9 This discovery was quickly followed by the discovery of cap-adjacent m6A methylation of ribose …

The enzyme responsible for the N6-methylation on the mRNA cap-adjacent Am-modified nucleotide was recently identified as the cap-specific MTase, CAPAM (/PCIF1) (47,52,54,97), …