These LysMcre mice may be useful for Cre-lox studies of the myeloid cell lineage (monocytes, mature macrophages and granulocytes) and the innate immune response.

For mature macrophage populations, about 90–100% alveolar macrophages and peritoneal macrophages were LysM +, whereas only 40% of spleen red pulp or spleen marginal zone …

In 1999, a myeloid-specific Cre-expressing mouse line, LysM-Cre, was generated by Förster and colleagues through directly inserting engineered Cre cDNA into the endogenous lysozyme 2 …

Nov 8, 2019 · These findings indicate that loss of LysM and expression of Cre recombinase are non-contributory in sterile acute lung injury. Lysozyme is an important component of the innate …

3 days ago · The Cre-recombined RanBP9-TurnX model revealed a lung proteome with enrichment of interactions in LysM-Cre POS cells listing proteins that are mostly expressed in …

May 15, 2018 · In the LysM + myelomonocytic cells of the experimental mice, the transgene A will be knocked out while LysM − cells remain unaffected. This type of cell- or tissue-specific gene …

Mar 9, 2020 · LysM-cre is expressed in macrophages and a subset of microglia together with a small but significant recombination of LysM-cre in the retinal neurons of adult mice. Cdh5 also …

Mar 18, 2025 · View Lyz2<tm1(cre)Ifo> allele: origin, molecular description and human disease models, images, gene associations, and references.

Sep 11, 2014 · In IL-4Rα flox/Δ LysM Cre mice, LysM Cre results in the elimination of only mature IL-4Rα + Arg1 + Lyz2 hi AAMs. The loss of this subset of AAMs results in the failure to …

Myeloid cells highly express the isoform, lysozyme M, and its promoter has been used to direct Cre recombinase expression to target deletion of floxed genes in myeloid cells. However, …