Jan 23, 2023 · The mRNA-Luc LNP solution (0.5 mL) containing 0.1 mg/mL encapsulated mRNA was freeze-dried in a penicillin bottle. Lyophilized LNPs were reconstituted using 0.5 mL of …

Mar 18, 2025 · Using firefly luciferase (Luc) as a reporter mRNA, we evaluated the physical–chemical properties, stability, and biodistribution of an LNP-mRNA formulation …

Here, we have developed a library of N-series lipid nanoparticles (LNPs) that could specifically regulate the protein composition of protein corona on the surface of LNPs, which allows …

Nov 20, 2022 · Here, we show that a novel and liver-targeted ionizable lipid nanoparticle delivery system for mRNA encoding B7H3×CD3 BiTE exerts potent antitumor activity against …

Lipid Nanoparticles (LNPs) represent the most effective and safe delivery systems for the translational success of nucleic acid drugs. NanOZ LNP-RNA is designed to not only protect …

Dec 8, 2021 · Here we report a chemically defined lipid nanoparticle (LNP) system which is able to deliver Cas9 mRNA and sgRNA into skeletal muscle by repeated intramuscular injections.

Dec 13, 2022 · In nonhuman primates, the LNP-encapsulated mRNA encoding SARS-CoV-2 spike protein induced robust, durable, and broad antibody responses against the six strains, …

We screened LNPs for luciferase mRNA delivery and identified formulations that accumulate within fetal livers, lungs, and intestines with higher efficiency and safety compared to …

Long-term storage of mRNA-LNP vaccines requires freezing, posing a limitation for this successful, novel vaccine class. Pardi and colleagues demonstrate that lyophilization provides …

Here, we investigate the prop-erties of LNP mRNA systems prepared with high levels of “help-er lipids such as 1,2-distearoyl-sn-glycero-3-phosphorylcholine ” (DSPC) or N-(hexadecanoyl) …