Lipoprotein-associated phospholipase A 2 (Lp-PLA 2) also known as platelet-activating factor acetylhydrolase (PAF-AH) is a phospholipase A 2 enzyme that in humans is encoded by the PLA2G7 gene. [5] [6] Lp-PLA 2 is a 45-kDa protein of 441 amino acids. [7] It is one of several PAF acetylhydrolases.

Lp-PLA 2 is a calcium-independent serine lipase of 50-kDa which hydrolyzes the acetyl group at the sn-2 position of platelet-activating factor. About 80% of Lp-PLA 2 circulates bound to low-density lipoprotein (LDL) particles, whereas the remaining 20% is bound to high-density lipoprotein (HDL).

Jan 15, 2021 · Lp-PLA2 is linked to the amount of plaque in the blood and can act as an early warning sign. Find out if you should test Lp-PLA2. Whether your Lp-PLA2 levels are normal, and what you can do to improve them. What is Lp-PLA2?

Jan 1, 2020 · The PLAC test is a blood test used to measure serum activity of lipoprotein-associated phospholipase A2 (Lp-PLA2), an enzyme that breaks down oxidized low-density lipoprotein in the...

Novel pathogenic, epidemiologic, genetic, and crystallographic studies regarding Lp‐PLA2 have been reported recently, while novel inhibitors were identified through a fragment‐based lead discovery strategy.

The PLAC® test for Lp-PLA 2 Activity is an enzyme assay for the in vitro quantitative determination of Lp-PLA 2 (lipoprotein-associated phospholipase A2) activity in EDTA plasma and serum.

Dec 20, 2021 · LP-PLA2 is an independent marker for the risk of developing CVD. It involves venipuncture, so it cannot be used in individuals with coagulopathies. It can be used to identify patients who have normal LDL but are at risk.

Lp-PLA 2, or lipoprotein-associated phospholipase-A 2, measures disease activity within the artery wall below the collagen or calcified cap due to the activation of macrophages. Lp-PLA 2 is not an acute phase reactant. When disease is active in the artery, increased levels of Lp-PLA 2 are produced by macrophages and

Lipoprotein-associated phospholipase A2 (Lp-PLA2) is deemed to play a role in atherosclerosis and plaque destabilization as demonstrated in animal models and in prospective clinical studies. However, most of the literature is either focused on ...

Sep 27, 2016 · Can lipoprotein-associated phospholipase A2 (Lp-PLA2) serve as a useful tool for risk stratification? Lp-PLA2 and surrogate markers of subclinical cardiovascular disease such as coronary artery calcification, endothelial dysfunction, and carotid intima-media thickness.