We have developed a new clinical score called the LOgistic Regression-based Immunotherapy-response Score (LORIS) using a transparent and concise 6-feature logistic regression model.

We have developed a new clinical score called the LOgistic Regression-based Immunotherapy-response Score (LORIS) using a transparent and concise 6-feature logistic regression model. LORIS outperforms previous signatures in ICB response prediction and can identify responsive patients, even those with low tumor mutational burden or tumor PD-L1 ...

Jun 3, 2024 · We developed a clinical score called LORIS (logistic regression-based immunotherapy-response score) using a six-feature logistic regression model. LORIS outperforms previous signatures in...

Jun 4, 2024 · LORIS consistently predicts patient objective response and short-term and long-term survival across most cancer types. Moreover, LORIS showcases a near-monotonic relationship with ICB response probability and patient …

Jun 3, 2024 · They have made their AI model, called Logistic Regression-Based Immunotherapy-Response Score (LORIS), publicly available at https://loris.ccr.cancer.gov. The tool estimates the likelihood of a patient responding to immune checkpoint inhibitors based on data on the six variables described above.

Feb 26, 2025 · In 2024, Dr. Ruppin’s lab at NCI, in collaboration with Dr. Chowell’s team and other researchers, reported the results of a study using a prediction model similar to SCORPIO that they had developed, called LORIS.

In this episode, we hear from Dr. Eytan Ruppin, Dr. Tiangen Chang, and Dr. Yingying Cao, computational scientists at NCI's Center for Cancer Research. They discuss their newly developed AI tool, LORIS, which can predict how a patient will respond to immunotherapy.

Jun 3, 2024 · The model, named LORIS, accurately forecasts patient response and survival, even identifying patients with low tumor mutational burden who might still benefit from immunotherapy. The AI model is publicly available and aims to assist doctors in making informed decisions about immunotherapy treatments, with further validation needed in larger ...

Jun 3, 2024 · They have made their AI model, called Logistic Regression-Based Immunotherapy-Response Score (LORIS), publicly available at https://loris.ccr.cancer.gov. The tool estimates the likelihood of a ...

The pan-cancer LORIS tool is available online at LORIS_NCI. An online calculator featuring all four models—pan-cancer LLR6, pan-cancer LLR5 (without patient systemic therapy history), NSCLC-specific LLR6, and NSCLC-specific LLR5 (without patient systemic therapy history)—is available at LORIS_web.