Lipid rafts influence membrane fluidity and membrane protein trafficking, thereby regulating neurotransmission and receptor trafficking. [3] [6] Lipid rafts are more ordered and tightly packed than the surrounding bilayer, but float freely within the membrane bilayer. [7]

Lipid rafts are microdomains of the plasma membrane enriched in cholesterol and sphingolipids, and play many important roles in cell signal transduction (Simons and Toomre, 2000). Lipid rafts are heterogeneous in both protein and lipid content, and coexist within a cell (Pike, 2005).

Lipid rafts are dynamic assemblies of proteins and lipids that float freely within the liquid-disordered bilayer of cellular membranes but can also cluster to form larger, ordered platforms. Rafts are receiving increasing attention as devices that regulate membrane function in …

Nov 14, 2003 · These microdomains are usually called lipid rafts, and many papers have suggested that rafts play a role in a wide range of important biological processes, including numerous signal transduction pathways, apoptosis, cell adhesion and migration, synaptic transmission, organization of the cytoskeleton, and protein sorting during both exocytosis ...

Mar 30, 2017 · Lipid rafts are relatively ordered membrane domains that are enriched in cholesterol and saturated lipids, and selectively recruit other lipids and proteins.

In a consensus definition of lipid rafts formulated at the 2006 “Keystone Symposium on Lipid Rafts and Cell Function” it was concluded that “Membrane rafts are small (10–200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched domains that …

Oct 1, 2000 · It is now becoming clear that lipid micro-environments on the cell surface — known as lipid rafts — also take part in this process. Lipid rafts containing a given set of proteins can change...

Apr 29, 2020 · Between these regimes is the mesoscale organization of cellular membranes into lipid-driven domains termed lipid rafts. This ultrastructural organization has fascinated and baffled a...

Jan 1, 2010 · Lipid rafts are fluctuating nanoscale assemblies of sphingolipid, cholesterol, and proteins that can be stabilized to coalesce, forming platforms that function in membrane signaling and trafficking.

Feb 19, 2020 · The lipid raft hypothesis postulates that lipid–lipid interactions can laterally organize biological membranes into domains of distinct structures, compositions, and functions. This proposal has in equal measure exhilarated and frustrated membrane research for decades.