Apr 24, 2024 · Our study revealed that the >10 KDa group was the main material basis of the leech extract that inhibited pulmonary fibrosis through TGF-β1/Smad3 signaling pathway.

Mar 1, 2024 · Leech extract was discovered in the late 19th century and since then many pharmaceutical products have been produced using leech extract for different ailments, but many have been withdrawn. Ongoing studies focus on developing health authority compliant pharmaceuticals to be used as modern medicine.

Jan 10, 2021 · Leech extract treatment under a hypertensive condition exerted significant cardio-protective benefits by reducing the expression of cardiac hypertrophy-related transcription factors, stress-associated MAPKs, and fibrosis mediators.

Jan 10, 2021 · In this study, we aimed to delineate the molecular mechanisms of medicinal leech extract in the treatment of cardiac hypertrophy and fibrosis, using both in vitro and in vivo assessments.

Medicinal leech therapy (MLT) or hirudotherapy, an old technique, has been studied by many researchers for possible effects on various diseases such as inflammatory diseases, osteoarthritis, and after different surgeries.

They outlined that leech extract could be used in the treatment of bacteria-induced illnesses including arthritis, foodborne disorders, and nosocomial infections. They also highlighted a beneficial usage of the leech extract in cleaning products for hospital disinfection and the daily domestic cleaning[ 78 ].

Dec 13, 2024 · Leech saliva contains versatile peptides and molecules that can exert anti-microbial, anti-inflammatory, anti-coagulant, and analgesic activities on the patients.

Apr 24, 2024 · Our study revealed that the >10 KDa group was the material basis of the extract of leech in treatment of pulmonary fibrosis, which can not only inhibit TGF-β1-induced lung fibroblasts differentiation and ECM of HFL1 cells but also alleviate BLM-induced PF in mice by up-regulating the expression level of PKM2 monomer and Smad7 protein.

The purpose of this review was to discuss the development of leech extract as a therapeutic agent, including the evolution of extraction techniques, and the successful manufacturing of leech extract-based pharmaceuticals.

Our preliminary studies have demonstrated that the leech extract group with molecular weight greater than 10 kDa (>10 kDa group) exhibited superior anti-idiopathic pulmonary fibrosis efficacy. To trace the active components of > 10 kDa group, it was separated by gel electrophoresis and analyzed by Nano LC-MS/MS. To further analyze the effects ...