Role of Histone Deacetylases in Gene Regulation at Nuclear Lamina
Nov 30, 2012 · Our data reveal the major role for HDAC1 in mediating deacetylation, chromatin compaction, and gene silencing in the multigenic domain, and an auxiliary role for HDAC3 that …
Statins and Histone Deacetylase Inhibitors Affect Lamin A/C – …
Jan 31, 2019 · Class I HDACs, encompassing HDAC1, HDAC2, HDAC3, and HDAC8, are ubiquitously expressed and are mainly localized within the nucleus, where they deacetylate …
NUP98 and RAE1 sustain progenitor function through HDAC
Jun 23, 2023 · NUP98’s chromatin binding sites are co-occupied by HDAC1. HDAC inhibition diminishes NUP98’s chromatin binding and dysregulates NUP98 and RAE1’s target gene …
Aging-related chromatin defects via loss of the NURD complex
The in vivo physical interaction of lamin A with RBBP4, RBBP7 and HDAC1 observed here, and previously suggested by biochemical fractionation 19, points towards a regulatory role for the …
EGFR phosphorylates HDAC1 to regulate its expression and anti …
May 11, 2021 · HDAC1 is the prototypical human histone deacetylase (HDAC) enzyme responsible for catalyzing the removal of acetyl group from lysine residues on many substrate …
Role of HDAC1 complexes in gene regulation at the nuclear lamina
Apr 1, 2013 · In Drosophila, Lamin B has been shown to be involved in the transcriptional repression of multigenic regions located at the nuclear periphery through histone deacetylation …
Divergent roles of HDAC1 and HDAC2 in the regulation of …
Dec 11, 2013 · Our data reveal a crucial function of HDAC1/HDAC2 in the control of lineage specificity and a novel role of HDAC1 as a tumour suppressor in the epidermis. Keywords: …
The histone deacetylase Hdac1 regulates inflammatory signalling …
Hdac1 is a major nuclear HDAC controlling IL-1β-dependent inflammatory response in IEC, notably by regulating gene-specific transcriptional responses. Hdac1 may be important in …
Role of Histone Deacetylases in Gene Regulation at Nuclear …
Nov 30, 2012 · Our data reveal the major role for HDAC1 in mediating deacetylation, chromatin compaction, and gene silencing in the multigenic domain, and an auxiliary role for HDAC3 that …
Dynamic distribution of HDAC1 and HDAC2 during mitosis ... - PubMed
HDAC1 and 2 are components of corepressor complexes, which function with lysine acetyltransferases to catalyze dynamic protein acetylation and regulate gene expression. In …