The Lavochkin-Gorbunov-Gudkov LaGG-3 (Лавочкин-Горбунов-Гудков ЛаГГ-3) was a Soviet fighter aircraft of World War II. It was a refinement of the earlier LaGG-1 and was one of the most modern aircraft available to the Soviet Air Force at the time of Germany 's invasion in 1941.

The LAG-2 membrane protein is a putative signaling ligand for the LIN-12 and GLP-1 receptors of Caenorhabditis elegans. LAG-2, like its Drosophila homologues Delta and Serrate, acts in a conserved signal transduction pathway to regulate cell fates during development.

The LAG-2 membrane protein is a putative signaling ligand for the LIN-12 and GLP-1 receptors of Caenorhabditis elegans. LAG-2, like its Drosophila homologues Delta and Serrate, acts in a conserved signal transduction pathway to regulate cell fates during development.

The C. elegans lag-2 gene is required for several cell-cell interactions that rely on the receptors GLP-1 and LIN-12. In this paper, we report that lag-2 encodes a putative membrane protein with sequence similarity to Drosophila Delta, a proposed ligand for the Notch receptor.

Oct 1, 1994 · The C. elegans lag-2 gene is required for several cell-cell interactions that rely on the receptors GLP-1 and LIN-12. In this paper, we report that lag-2 encodes a putative membrane protein with sequence similarity to Drosophila Delta, a proposed ligand for the Notch receptor.

Mar 10, 1994 · We report here that lag-2 encodes a predicted transmembrane protein of 402 amino acids. The predicted extracellular region of lag-2 is similar to amino-terminal regions of Delta and Serrate, two Drosophila proteins that are thought to function as ligands for Notch.

Aug 8, 2017 · LAG-2, a founding DSL ligand family member, is produced in the DTC and activates the GLP-1/Notch receptor on adjacent germ cells to maintain germline stem cell fate. Here, we show that DAF-7/TGFβ signaling promotes expression of lag-2 in the DTC in a daf-3- …

Aug 1, 2011 · lag-2 encodes a ligand for LIN-12 /Notch and is a component of the lateral signal that activates LIN-12 /Notch during Caenorhabditis elegans vulval precursor cell (VPC) fate patterning. lag-2 is specifically transcribed in one VPC, named P6.p, in response to activation of EGFR/Ras/MAPK by the inductive signal that initiates vulval development.

Nov 1, 1994 · In this paper, we report that lag-2 encodes a putative membrane protein with sequence similarity to Drosophila Delta, a proposed ligand for the Notch receptor. Furthermore, we show that the...

Sep 9, 2019 · All LAG-2::GFP expression was lost in the proximal gonad in the hlh-2(Δprox) background, indicating that LAG-2 expression also occurs in conjunction with the endowment of AC potential by hlh-2. The presence of surface LAG-2::GFP suggests that they are poised to activate LIN-12 in neighboring cells.