LPS is known to signal through the TLR4 signaling pathway, which plays a role in the production of inflammatory cytokines including pro-IL-1β through activating the NF-κB and MAPK pathway 35,36,37. We therefore investigated the activation of the TLR4 signaling pathway in LPS-stimulated macrophages.

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Sep 7, 2021 · This event generates every time a process runs using the non-current access token, for example, UAC elevated token, RUN AS different user actions, scheduled task with defined user, services, and so on. IMPORTANT: this event is deprecated starting from Windows 7 and Windows 2008 R2.

Aug 12, 2020 · Structural and physiological studies show that the inner membrane protein PbgA is a crucial sensor of lipopolysaccharide (LPS) and regulates the activity of the LPS biosynthesis enzyme LpxC.

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革兰阴性菌OMVs的产生是一种包膜应激反应,当革兰阴性菌的周质中存在错误折叠的蛋白质废物、PG片段和LPS片段时,这些废物会被包裹在OMVs中并释放[8]。 因此在革兰阴性菌中缺失参与修复和/或消除错误折叠的周质蛋白基因,基因缺失突变株都会表现出OMVs产量增加。 人工诱导蛋白质废物在周质中积累主要是通过缺失蛋白酶基因或缺失参与σE包膜应激反应途径的蛋白质来实现。 通常认为DegP蛋白在高温下主要作为蛋白酶发挥水解蛋白质的作用,以消除未折叠的[13]外膜 …

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