AKT1, LKB1, and YAP1 Revealed as MYC Interactors with NanoLuc …
The MYC interactions with AKT1, LKB1, and YAP1 were confirmed by coimmunoprecipitation of endogenous proteins. Importantly, AKT1, LKB1, and YAP1 were able to activate MYC in a …
Repression of LKB1 by miR-17∼92 Sensitizes MYC-Dependent …
May 19, 2020 · Using both classic (phenformin) and newly developed (IM156) biguanides, we demonstrate that elevated miR-17∼92 expression in Myc+ lymphoma cells promotes …
The LKB1–AMPK pathway: metabolism and growth control in
LKB1 acts a master upstream kinase, directly phosphorylating and activating AMP-activated protein kinase (AMPK) and a family of 12 related kinases that have crucial roles in cell growth,...
AKT1, LKB1, and YAP1 Revealed as MYC Interactors with NanoLuc …
Nov 23, 2016 · We validated three promising MYC interactors (AKT1, LKB1, and YAP1), revealing their functional importance in the regulation of oncogenic MYC. The established NanoPCA PPI …
LKB1; linking cell structure and tumor suppression | Oncogene
Nov 24, 2008 · Lkb1 regulates cell polarity through downstream kinases including AMPKs, MARKs and BRSKs, and nutrient utilization and cellular metabolism through the AMPK–mTOR …
LKB1 tumor suppressor regulates AMP kinase/mTOR-independent …
Oct 1, 2012 · Restoration of LKB1 expression in HeLa cells, which lack this tumor suppressor, or short-hairpin RNA knockdown of LKB1 in NTERT immortalized keratinocytes, demonstrated …
The LKB1 tumor suppressor negatively regulates mTOR signaling
Here, we report that LKB1 is required for repression of mTOR under low ATP conditions in cultured cells in an AMPK- and TSC2-dependent manner, and that Lkb1 null MEFs and the …
Suppression of oncogenic properties of c-Myc by LKB1-controlled ...
Sep 11, 2007 · The results together expose surprising proliferation and apoptosis resistance of organized epithelial structures and identify a role for the polarity regulator LKB1 in the …
LKB1 tumor suppressor protein regulates actin filament assembly …
Oct 12, 2010 · LKB1 was immunoprecipitated from cell lysates with anti-myc (lanes 1 and 3), or control IgG (lane 2) antibody and analyzed by western blot analysis. Dbl was detected using a …
Abstract 5220: Reciprocal regulation of MYC and LKB1 modulates …
Oct 1, 2014 · In this study, we report a reciprocal regulation between MYC and LKB1 which modulates cell survival and differentiation in non-small cell lung cancer (NSCLC). We found …