Lymphoid enhancer-binding factor-1 (LEF1) is a 48-kD nuclear protein that is expressed in pre- B and T cells. It binds to a functionally important site in the T-cell receptor-alpha (TCRA) …

Jun 21, 2021 · Lymphoid enhancer binding factor 1 (LEF1) is a transcription factor for B and T cells and is involved in the Wnt / CTNNB1 pathway which regulates normal development of …

Mar 30, 2025 · LEF1 (Lymphoid Enhancer Binding Factor 1) is a Protein Coding gene. Diseases associated with LEF1 include Split Hand-Foot Malformation and Ectrodactyly And Ectodermal …

Oct 6, 2021 · Using high-throughput chromosome-conformation-capture sequencing, we demonstrate that Tcf1/Lef1 are important for maintaining three-dimensional genome …

Lymphoid enhancer-binding factor 1 (LEF1), a member of the T-cell Factor (TCF)/LEF1 family of high-mobility group transcription factors, is a downstream mediator of the Wnt/β-catenin …

Recently, the role of lymphocyte enhancer-binding factor 1 (LEF1) in CLL was elucidated being highly expressed and seeming to have a prognostic value. Our aim was to test the applicability …

Feb 8, 2025 · LEF-1 binds specifically to the major histocompatibility complex class I-like protein CD1D promoter; enhanced expression of LEF1 in K562 or Jurkat cells suppresses CD1D …

Jun 1, 2017 · Lymphoid enhancer-binding factor 1 (LEF1), a member of the T-cell Factor (TCF)/LEF1 family of high-mobility group transcription factors, is a downstream mediator of the …

LEF1 is a nuclear protein that is expressed in pre-B and T cells. It binds to a functionally important site in the T-cell receptor-alpha (TCRA; see 186880) enhancer and confers maximal enhancer …

Jun 17, 2011 · Our results demonstrate that nuclear overexpression of LEF1 is highly associated with chronic lymphocytic leukemia/small lymphocytic lymphoma, and may serve as a …