L cells secrete glucagon-like peptide-1, an incretin, peptide YY 3-36, oxyntomodulin and glucagon-like peptide-2. L cells are primarily found in the ileum and large intestine (colon), but …

With a view to home in on what an L-cell is, we here present an overview of available data on L-cell development, L-cell peptide expression profiles, peptide production and secretory patterns …

Nov 25, 2022 · L cells are neuroendocrine cells producing glucagon-like peptide 1 (GLP1), glucagon-like peptide 2 (GLP2), peptide YY (PYY), glicentin (Fig. 1), and oxyntomodulin …

L-cells, which have traditionally been described as having a distinct cone-shaped morphology, secrete the products of cleavage by prohormone convertase 1; GLP-1, glucagon-like peptide 2 …

Enteroendocrine L-cells have mainly been studied for their function as regulators of postprandial response to nutrients. One prominent feature of L-cells is the expression of the proglucagon …

Dec 1, 2006 · Early studies on L-cell secretagogues used antibodies that targeted a mid-sequence epitope of glucagon, resulting in detection of glicentin/oxyntomodulin (i.e., …

Feb 20, 2025 · L cells are a type of enteroendocrine cell primarily found in the ileum and large intestine (colon), with some also present in the duodenum and jejunum. Their primary function …

Feb 26, 2019 · Enteroendocrine cells are specialized cells found within the gastrointestinal tract, stomach and pancreas. They produce and release hormones in response to a number of stimuli.

These findings expand traditional concepts of enteroendocrine L cell biology to encompass the sensing of inflammatory stimuli and compromised mucosal integrity, linking glucagon-like …

Jan 16, 2014 · Here we present a novel in vitro platform to generate functional L cells from three-dimensional cultures of mouse and human intestinal crypts. We show that short-chain fatty …