Potassium voltage-gated channel subfamily D member 2 is a protein that in humans is encoded by the KCND2 gene. [5][6][7] It contributes to the cardiac transient outward potassium current (I to1), the main contributing current to the repolarizing phase 1 of the cardiac action potential. [8]

Rapidly activating and rapidly inactivating voltage-gated A-type K + currents, IA, are key determinants of neuronal excitability and several studies suggest a critical role for the Kv4.2 pore-forming α subunit in the generation of IA channels in hippocampal and cortical pyramidal neurons.

Sep 22, 2021 · Here we report cryo-electron microscopy structures of the Kv4.2–DPP6S–KChIP1 dodecamer complex, the Kv4.2–KChIP1 and Kv4.2–DPP6S octamer complexes, and Kv4.2 alone.

Kv4.2 is a Shal-type potassium channel that passes an A-type current and is localized to dendrites and cell bodies in the hippocampus. The sequence of Kv4.2 contains several consensus sites for ERK phosphorylation.

Seizures in Kv4.2 transgenic mice rapidly redistribute K+ channel subunit Kv4.2 to the neuronal surface, implicating a molecular substrate for the increased K+ current.

Using histoblot and immunoelectron microscopic techniques, we investigated the expression, regional distribution and subcellular localisation of Kv4.2 and Kv4.3 in the adult brain, as well as the ontogeny of their expression during postnatal development.

Mar 19, 2025 · To address this gap, we introduced a Kv4.2-specific antibody (anti-Kv4.2) into hippocampal neurons of mice of both sexes to selectively inhibit postsynaptic Kv4.2, enabling direct examination of its impact on excitatory postsynaptic potentials (EPSPs) and currents (EPSCs) during basal synaptic activity.

Here we demonstrate a direct interaction between Kv4.2 and the actin-binding protein, filamin. We show that Kv4.2 and filamin can be coimmunoprecipitated both in vitro and in brain and that Kv4.2 and filamin share an overlapping expression pattern in …

Apr 6, 2006 · Here, we report that Kv4.2 mediates the majority of A-type current in dorsal horn neurons and is a critical site for modulation of neuronal excitability and nociceptive behaviors.

Kv4.2 (also known as RK5; KIAA1044; MGC119702; MGC119703), encoded by the gene KCND2, is a member of the potassium voltage-gated channel subfamily D. Kv4.2 is the main contributing current to the repolarizing phase 1 of the cardiac action potential.