Jan 2, 2025 · This review examines the giant elastic protein titin and its critical roles in heart function, both in health and disease, as discovered since its identification nearly 50 years ago. Encoded by the TTN (titin gene), titin has emerged as a major disease locus for cardiac disorders.

Feb 26, 2013 · Titin is a giant multi-functional sarcomeric filament that provides passive stiffness to cardiac myocytes. At its N terminus, titin is embedded in the Z-disk of the sarcomere.

Titin is a large abundant protein of striated muscle. Titin's primary functions are to stabilize the thick filament, center it between the thin filaments, prevent overstretching of the sarcomere, and to recoil the sarcomere like a spring after it is stretched. [42]

Titin functions as a molecular spring that gives rise to passive tension mainly through three extensible segments located in the I-band: the tandem immunoglobulin (Ig)-like domain, the repeating PEVK [proline (P), glutamate (E), valine (V) and lysine (K)] domain, and N2B domain (Labeit and Kolmerer, 1995).

Oct 18, 2021 · The giant sarcomere protein titin is a major determinant of cardiomyocyte stiffness and contributor to cardiac strain sensing. Titin-based forces are highly regulated in health and disease, which aids in the regulation of myocardial function, including cardiac filling and output.

Ktp Titin Fatmawati 2021-1 - Free download as PDF File (.pdf) or read online for free.

Formulir ini berisi permohonan untuk membuat dan memperbaharui KTP dan KK. Formulir harus diisi dengan huruf besar dan tinta hitam, lalu diserahkan kembali ke kantor desa/kelurahan. Terdapat kolom untuk data diri pemohon, alamat, dan daftar anggota keluarga.

Sep 25, 2009 · In this issue of Circulation Research, Hidalgo et al present an elegant set of experiments that reveal a novel mechanism whereby altering the phosphorylation state of titin modulates myocardial passive stiffness. 2 Specifically, they demonstrated that titin, in addition to being a protein kinase (PK)A and PKG substrate, is also a PKCα ...

In this review, we discuss post-transcriptional and post-translational modifications of titin and address their roles in acquired disease, including dilated cardiomyopathy (DCM) and heart failure with preserved ejection fraction (HFpEF) (often termed diastolic heart failure).

Jan 2, 2025 · Encoded by the TTN (titin gene), titin has emerged as a major disease locus for cardiac disorders. Functionally, titin acts as a third myofilament type, connecting sarcomeric Z-disks and M-bands, and regulating myocardial passive stiffness and stretch sensing.