KLF4 - Wikipedia
Krüppel-like factor 4 (KLF4; gut-enriched Krüppel-like factor or GKLF) is a member of the KLF family of zinc finger transcription factors, which belongs to the relatively large family of SP1-like transcription factors.
Krüppel-like factor 4 (KLF4): What we currently know - PMC
Krüppel-like factor 4 (KLF4) is an evolutionarily conserved zinc finger-containing transcription factor that regulates diverse cellular processes such as cell growth, proliferation, and differentiation. Since its discovery in 1996, KLF4 has been ...
KLF4 Gene - GeneCards | KLF4 Protein | KLF4 Antibody
Mar 30, 2025 · KLF4 (KLF Transcription Factor 4) is a Protein Coding gene. Diseases associated with KLF4 include Hematologic Cancer and Glioma Susceptibility 1. Among its related pathways are Gene expression (Transcription) and Transcriptional regulation of …
KLF4: a multifunctional nexus connecting tumor progression and …
KLF4 plays a promoter role in tumorigenesis and development, or tumor suppressor as a context-dependent anti- and pro-inflammatory factor. KLF4 over-expression increases CD8+T cell differentiation and enhances the antitumor immunity.
KLF4 transcription factor in tumorigenesis | Cell Death Discovery
Apr 8, 2023 · In this review, we will summarize the structural and functional aspects of KLF4, with a focus on KLF4 as a clinical biomarker and therapeutic target in different types of tumors.
KLF4 KLF transcription factor 4 [ Homo sapiens (human) ]
Mar 26, 2025 · KLF4 regulates trophoblast function and associates with unexplained recurrent spontaneous abortion. KLF4-induced upregulation of SOCS1 ameliorates myocardial ischemia/reperfusion injury by attenuating AC16 cardiomyocyte damage and enhancing M2 macrophage polarization. KLF4 Induces Colorectal Cancer …
Recent Discoveries on the Involvement of Krüppel-Like Factor 4 in …
Krüppel-like factor 4 (KLF4) is a transcription factor highly conserved in evolution. It is particularly well known for its role in inducing pluripotent stem cells. In addition, KLF4 plays many roles in cancer. The results of most studies suggest ...
Krüppel-like factor 4 (KLF4): What we currently know - PubMed
May 5, 2017 · Krüppel-like factor 4 (KLF4) is an evolutionarily conserved zinc finger-containing transcription factor that regulates diverse cellular processes such as cell growth, proliferation, and differentiation.
Krüppel-like factor 4 (KLF4): What we currently know
May 5, 2017 · Krüppel-like factor 4 (KLF4) is an evolutionarily conserved zinc finger-containing transcription factor that regulates diverse cellular processes such as cell growth, proliferation, and differentiation.
KLF4 is involved in the organization and regulation of ... - Nature
Sep 23, 2019 · Here, using KLF4 as a paradigm, we provide a transcription-factor-centric view of chromatin reorganization and its association with three-dimensional enhancer rewiring and transcriptional...