Apr 7, 2010 · KLF15 inhibits p53 function by reducing abundance of acetylated p53. Conversely, Klf15 deficiency leads to p53 hyperacetylation and enhanced p53 effector functions, findings that are recapitulated in human disease.

KLF15 activation inhibits p300-mediated acetylation of p53. Conversely, Klf15 deficiency leads to hyper acetylation of p53 in the heart and aorta, a finding that is recapitulated in human tissues. Finally, Klf15-deficient mice are rescued by p53 deletion or p300 inhibition.

KLF15 activation represses the acetyltransferase p300 mediated acetylation of p53 to maintain normal heart function . Conversely, KLF15 deficiency leads to hyperacetylation of p53 in the mice hearts and in human hearts.

May 16, 2018 · In this paper, we underscored the important relationship between KLF15 and cardiovascular diseases such as atherosclerosis, heart failure, arrhythmia, aortic lesions, etc. On this basis, we identified KLF15 as a potential therapeutic target for the treatment of …

Sep 1, 2021 · The relationship between KLF15 and p53 was verified by si-KLF15 and PFTβ (a p53-specific inhibitor). Key findings: Here, we observed that the increase in the level of miR-431-5p was accompanied by a decrease in the expression of Krüppel-like zinc finger transcription factor 15 (KLF15).

Apr 1, 2019 · KLF15 knockout mice developed heart failure and aortic aneurysms through a p53- and p300 acetyltransferase- dependent mechanisms. Acetylation of p53 by p300 could be inhibited by KLF15 activation. Conversely, KLF15 deficiency in mice caused hyperacetylation of p53 in the aorta and heart.

Schematic representing KLF15 as a regulator of cardiac lipid flux. We show that cardiac KLF15, which is robustly induced during physiologic states, such as fasting and postnatal development, cooperates with p300 to regulate key metabolic targets.

KLF15 inhibits p53 function by reducing abundance of acetylated p53. Conversely, Klf15 deficiency leads to p53 hyperacetylation and enhanced p53 effector functions, findings that are recapitulated in human disease.

Sep 3, 2013 · We demonstrated that KLF15 alters the acetylation status and activity of the proinflammatory factor NF-κB through direct interaction with the histone acetyltransferase p300. These studies identify a previously unrecognized KLF15-dependent pathway that regulates VSMC proinflammatory activation.

Aug 30, 2016 · Here, we show that the fasting-induced transcription factor KLF15, a key regulator of gluconeogenesis, forms a complex with LXR/RXR, specifically on the Srebf1 promoter.