Sodium-calcium exchanger - Wikipedia
The sodium-calcium exchanger (often denoted Na+/Ca2+ exchanger, exchange protein, or NCX) is an antiporter membrane protein that removes calcium from cells. It uses the energy that is …
Structure-Based Function and Regulation of NCX Variants: …
The plasma-membrane homeostasis Na+/Ca2+ exchangers (NCXs) mediate Ca2+ extrusion/entry to dynamically shape Ca2+ signaling/in biological systems ranging from …
Mitochondrial localization of NCXs: Balancing calcium and …
Mar 1, 2020 · In this review, we will specifically focus on the Na+ /Ca 2+ exchanger (NCX) – one of the master regulators of cell Ca 2+ cycling – and discuss recent observations that point to a …
Structural mechanisms of the human cardiac sodium-calcium
Oct 4, 2023 · Na + /Ca 2+ exchangers (NCX) transport Ca 2+ in or out of cells in exchange for Na +. They are ubiquitously expressed and play an essential role in maintaining cytosolic Ca 2+ …
The SLC8 gene family of sodium-calcium exchangers (NCX)
Molecular silencing/overexpression of NCX in cellular systems and organ-specific KO mouse models provided useful information on the contribution of distinct NCX variants to cellular and …
Structural insight into the allosteric inhibition of human sodium ...
Dec 15, 2023 · Crystal structures of bacterial NCX from archaebacterial Methanococcus jannaschii (mjNCX) reveal the arrangement of ten transmembrane helices and four ion binding …
Role of Sodium-Calcium Exchanger in Modulating the Action …
Jun 12, 2003 · Increased Na + -Ca 2+ exchange (NCX) activity in heart failure and hypertrophy may compensate for depressed sarcoplasmic reticular Ca 2+ uptake, provide inotropic support …
Human Macrophages and Monocytes Express Functional Na
Oct 25, 2012 · The Na+/Ca2+ exchanger (NCX) is a plasma membrane protein that can switch Na+ and Ca2+ in either direction to maintain the homeostasis of intracellular Ca2+. A family of …
Structural mechanisms of the human cardiac sodium-calcium …
Na + /Ca 2+ exchangers (NCX) transport Ca 2+ in or out of cells in exchange for Na +. They are ubiquitously expressed and play an essential role in maintaining cytosolic Ca 2+ homeostasis.
NCX1 and NCX3 as potential factors contributing to ... - Nature
Jun 25, 2018 · Na + -Ca 2+ exchanger (NCX) isoforms constitute the major cellular Ca 2+ extruding system in neurons and microglia. We herein investigated the role of NCX isoforms in …