The juxtaglomerular cell is a cell that is located near the glomerulus, hence its name. Similar to cardiac tissue, juxtaglomerular cells harbor β1 adrenergic receptors . When stimulated by epinephrine or norepinephrine , these receptors induce the secretion of renin.

The juxtaglomerular apparatus consists of three types of cells: The juxtaglomerular apparatus is part of the kidney nephron, next to the glomerulus. It is found between afferent arteriole and the thick ascending limb of the loop of Henle (distal straight tubule) of the same nephron.

Apr 15, 2024 · The juxtaglomerular apparatus (JGA), also referred to as the juxtaglomerular complex, is a specialized region of the nephron formed by three different types of cells: macula densa, juxtaglomerular granular, and extraglomerular mesangial (Lacis) cells.

Nov 26, 2021 · A. Juxtaglomerular (JG) cells. They are modified smooth muscle fibers in the tunica media of the afferent arteriole (occasionally in the efferent arteriole) as it enters the vascular pole of the glomerulus. Here, the internal elastic lamina of the afferent arteriole is lacking.

JGC are surrounded by multiple cell types, including pericytes, endothelial cells, epithelial cells, VSMCs, mesangial cells, and macula densa cells. Direct cell-to-cell interaction will undoubtedly contribute to normal RPC functioning.

Juxtaglomerular cell (JGC) tumors (JGCT) are very rare renin-secreting tumors originating from the JG apparatus. JGCT diagnosis remains difficult, but JGCT should be suspected in young patients with severe hypertension and secondary hyperaldosteronism associated with the secretion of large amounts of renin, after the elimination of other much ...

Nov 21, 2023 · Juxtaglomerular cells or JG cells are modified smooth muscle cells present in the afferent arteriole. These cells are distinguished by their granulated cytoplasm.

JG cells are highly specialized endocrine cells that express renin in a cell-specific manner. JG cells account for less than 0.1% of all kidney cells. Renin is stored in granules and is secreted in response to specific stimuli.

The juxtaglomerular apparatus is composed of the macula densa cells present in the distal convoluted tubule (DCT), juxtaglomerular cells (present in the entire glomerular vasculature but more prominent in the afferent arteriole) and the glomerular afferent arteriole(AT) [1].

Almost a century after the discovery of the endocrine function of the kidney in regulating blood pressure and the role of renin secretion molecular mechanisms involved in prorenin synthesis, activation and secretion in juxtaglomerular (JG) cells remain incompletely understood.