JAK1 is a human tyrosine kinase protein essential for signaling for certain type I and type II cytokines.

Mar 30, 2025 · This gene is a key component of the interleukin-6 (IL-6)/JAK1/STAT3 immune and inflammation response and is a therapeutic target for alleviating cytokine storms. The kinase …

JH1 is the kinase domain important for the enzymatic activity of the JAK and contains typical features of a tyrosine kinase such as conserved tyrosines necessary for JAK activation (e.g., …

Nov 26, 2021 · In liver fibrosis, JAK1 is a constitutive TGFβRI-binding protein; thus, STAT3 is activated directly through JAK1 within minutes of TGFβ stimulation in a SMAD-independent …

Janus kinase (JAK) is a family of cytoplasmic non-receptor tyrosine kinases that includes four members, namely JAK1, JAK2, JAK3, and TYK2. The JAKs transduce cytokine signaling …

tyrosine-protein kinase JAK1. The Janus kinase 1 is critical for pancreatic cancer initiation and progression. Individuals with JAK1 variants are affected by syndromic features encompassing …

The Janus Kinase (JAK) family members serve essential roles as the intracellular signalling effectors of cytokine receptors. This family, comprising JAK1, JAK2, JAK3 and TYK2, was first …

Feb 20, 2024 · This gene is a key component of the interleukin-6 (IL-6)/JAK1/STAT3 immune and inflammation response and is a therapeutic target for alleviating cytokine storms. The kinase …

May 28, 2024 · Shrestha et al. demonstrate that JAK1 is a key signaling mediator of cytokines that promote mutant KRAS-induced pancreatic cancer initiation and progression.

Jul 16, 2024 · This review provides an updated overview of germline IEIs (and their somatic phenocopies) that disrupt human JAK-STAT signaling, with particular emphasis on recent …