Oct 27, 2020 · Integrin alpha V (ITGAV), a transmembrane glycoprotein responsible for cell-to-matrix binding has been found to enhance tumor progression in several tumor entities. The expression pattern and biological role of ITGAV expression in esophageal adenocarcinoma (EAC) has not been analyzed so far.

Our study reveals the potential of ITGAV as a diagnostic and prognostic biomarker, while also demonstrating its key regulatory role in immunotherapy and tumor metastasis, providing a promising novel target for digestive system cancers treatment options.

Integrin alpha V (ITGAV), a transmembrane glycoprotein responsible for cell‐to‐matrix binding has been found to enhance tumor progression in several tumor entities. The expression pattern and...

Sep 11, 2024 · We computationally integrate binding motifs of human integrin alphaV beta6, a skeletal muscle receptor, into a liver-detargeting capsid. Designed AAVs show higher productivity and superior muscle...

Dec 11, 2018 · DNMs promote the directional migration of MKs by affecting CXCR4 surface expression, ITGB1 activity, and RhoA activity. DNM-induced migration and cytoskeletal-membrane changes enable spatial control of proplatelet formation in the proper niche.

As expected, Itgav gene expression was significantly higher in Ctrl mice under basal conditions and in response to Ang II compared with α v SMKO mice. At baseline, there was also a lower expression of Col1a1 gene in α v SMKO mice as compared with Ctrl mice.

Feb 13, 2025 · Our results elucidated the importance of ITGAV in the prognostic assessment, early diagnosis, and targeted immunotherapy of digestive system cancers, and revealed its multifaceted role in regulating cancer progression.

Mar 30, 2025 · ITGAV (Integrin Subunit Alpha V) is a Protein Coding gene. Diseases associated with ITGAV include Visceral Myopathy 1 and West Nile Virus. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Integrin Pathway.

Oct 27, 2020 · Integrin alpha V (ITGAV), a transmembrane glycoprotein responsible for cell-to-matrix binding has been found to enhance tumor progression in several tumor entities. The expression pattern and...

Integrin alpha-V is a protein that in humans is encoded by the ITGAV gene. [5] ITGAV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain.