Protein A, B and C are isoforms encoded from the same gene through alternative splicing. A protein isoform, or " protein variant ", [1] is a member of a set of highly similar proteins that originate from a single gene and are the result of genetic differences. [2] .

In genetics, gene isoforms are mRNAs that are produced from the same locus but are different in their transcription start sites (TSSs), protein coding DNA sequences (CDSs) and/or untranslated regions (UTRs), potentially altering gene function.

Feb 1, 2018 · At its simplest, isoform generation provides a mechanism to specialize the properties of a gene or protein at one of three levels – DNA, messenger RNA (mRNA) or the sequence of amino acids in the protein itself (Figure 1).

Feb 29, 2024 · Here, we present IsoForma, an open-source R package for the relative quantification of PI within a single tool. Benchmarking IsoForma ’s performance against two existing workflows produced comparable results and improvements in speed.

W e present a first version of a human Isoform ORFeome, human isoORFeome v1.1 containing 1,423 isoforms from 506 genes, of which 917 were not previously available as ORF clones, that are clonally-derived and sequence-confirmed ORFs as a set of Gateway Entry clones ready for transfer to Gateway-compatible expression vectors.

Mar 30, 2016 · Alternative splicing imparts distinct functions through isoform-specific protein–protein interactions. The alternative splicing of transcripts is known to contribute to the …

Here we provide open access to 3D protein structure predictions for isoforms of 237,275 human transcripts. Individual predicted structures for CHESS 3 can be found in Isoform Search. Summary tables and all structures can be found in Downloads. Search your own protein structure against our database in Foldseek Search.

We introduce a classification scheme for protein isoforms, discover novel protein isoforms, and present the first protein inference algorithm for the direct incorporation of long-read transcriptome data to enable detection of protein isoforms previously intractable to MS-based detection.

Aug 27, 2011 · In higher eukaryotes many genes encode protein isoforms whose properties and biological roles are often poorly characterized. Here we describe systematic approaches for detection of either distinct isoforms, or separate pools of the same isoform, with differential biological properties.

Venn diagram showing the overlap between the number of genes that are intracellular, membrane-spanning, secreted, or with isoforms belonging to more than one of the three categories.